Master of Science II (Biotechnology)
Examination: Oct Nov 2016 Semester III (New CBCS)
SLR No. Day
Date Time Subject Name Paper
No. Seat No.
SLR SK
118
Wednesday
23/11/2016
02:30 P.M
To
05:00 P.M
Computational
Structure Biology
Drug Designing
C
XII
Es Instructions: Section Question 1 is compulsory.
From Section- II attempt any four
Figures to the right indicate full marks.
Answer to the Part-I Part- II are to be written in same
answer booklet only.
Total Marks: 70
Section- I
Q.1 Rewrite the following sentences by selecting correct answers from given
alternative.
07
The computational methodology that tries to find the best matching
between two molecules, a receptor and ligand is called

Molecular matching Molecular docking
Molecular affinity Molecular fitting
Proteomics is the study of
Set of proteins
Set of proteins in a specific region of the cell
Entire set of expressed proteins in a cell
None of the above
A compound that has desirable properties to become a drug like is called

Lead Fit drug
Non lead Both a b
of the following is one of the rules in Lipinski's rule
of five.
A molecular weight equal to 500
No more than five hydrogen bond acceptor group
No more than ten hydrogen bond donor group
A calculated logP value is less than
is visualization tool which tool does not recognize
PDB format.
Cn3D RasMol
RasTop PyMol
Neural network based secondary structure method is
PSIPRED GOR
PHD Both a&b
Page 1 of 2
database constructed almost entirely based on manual
examination of protein structures.
SCOP CATH
PDB Both CATH and SCOP
Define the following terms: 07
Drug efficacy
3D PSSSM
CYP450
PSI-PRED
Motiff
Domain
CRD
Section-II
Answer any four of the following:
Q.2 What is interactome? Explain the in detail Protein-Protein interaction and its
importance.
14
Q.3 Explain the molecular modeling steps and add a note on model validation. 14
Q.4 Explain the 3D structure prediction and explain fold recognition and threading
method in details.
14
Q.5 Answer any Two from the following: 14
Write a note on Quantitative Structure- Activity relationship
Explain in detail PDBeNMR, PDBechem, PDBeFold and PDBeMotif.
Write a note on mutation in drug target.
Q.6 Write shorts note onany TWO of the following: 14
Protein-DNA interaction prediction tool
ChemBank
Yeast three hybrid system