M.Sc.(Semester III) (CBCS) Examination Oct/Nov-2017
Nanotechnology
COMPUTATIONAL STRUCTURAL BIOLOGY AND DRUG DESIGN
Day Date: Saturday, 25-11-2017 Max. Marks: 70
Time: 02.30 PM to 05.00 PM
Instructions: Part Question 1 is compulsory.
Attempt any four questions from part II
Answers to the Part 1 and Part II are to be written in same answer
Booklet only.
Figures to the right indicate full marks.
Section I
Q.1 Rewrite the sentence after choosing the correct answer from the
given alternatives.
07
is a secondary structure prediction method.
Chou Fasman Threding
PDBsum Folding
Preclinical studies involve study.
Human Cell lines
Animals Both b c
PDB structure database is a part of
NDB DDJ
RCSB NCBI
Drugs combine with receptor and elicit appropriate response are
called
Antagonist Agonist
Affinity Efficacy
DIP is a interaction database.
DNA-DNA Protein Lipid
Protein protein Protein Ligand
CSA stands for
Critical Sequence Analysis Catalytic Site Atlas
Catalytic structure Atlas Catalytic Site Analysis
is the method used to design the drug using the knowledge
of 3D structure of protein.
Ligand based drug design
Structure based drug design
Non ligand based drug design
Non structure based drug design
Page 2 of 2
SLR-E-38
Definitions 07
Cytochrome p450
Swiss Model
Metacys
Lectin
Dihedral angle
Domain
LigPlot
Section II
Q.2 Answer any four of the following 14
What is yeast two hybrid system? Explain the mechanism of yeast two hybrid
systems for predicting Protein-Protein interaction.
Q.3 Write in detail on steps in homology modeling 3D structure predication
methods and a note on GOR secondary structure predication method.
14
Q.4 What is drug design? Explain drug designing parameters using Marvin sketch. 14
Q.5 Explain the detail the Drug Bank and Chem Bank. 14
Q.6 Answer any two from the following: 14
Write a note on protein protein interaction databases.
Explain Structural Visualization with its tool in details.
Describe Lipinski's rule of five and its importance in drug design.
Q.7 Write short notes on (any two) 14
PDB sum
Drug metabolism
RNA structure Predication