M.Sc. (Semester III) (CBCS) Examination Oct/Nov-2017
Biotechnology
COMPUTATIONAL STRUCTURE BIOLOGY DRUG DESIGNING
Day Date: Saturday, 25-11-2017 Max. Marks: 70
Time: 02.30 PM to 05.00 PM
Instructions: Section I Question 1 is compulsory.
Answer any four questions from Section II.
Figures to the right indicate full marks.
Answers to the Section I and Section II are to be written in same answer
Booklet only.
Section I
Q.1 Rewrite the sentence after choosing the correct answer from the given
alternatives:
07
The RNA secondary structure is mainly found in
Alpha Helix Hairpin loop
Beta sheet Coil
Model can be evaluating by
Procheck WHAT IF
ANOLEA All of these
Drugs combine with receptor and elicit appropriate response are called

Antagonist Agonist
Affinity Efficacy
The comparative modeling is also called as modeling.
Homology Fold
Primary Profile
is the drug metabolizing enzyme.
Protease Kinase
Cyp450 Lipase
is a method for validating chemical shift through structural data.
NMR clust NMR Core
OLDERDO VASCO
Pharmacodynamic properties
Efficacy Potency
Selectivity All of these
Define the following terms: 07
DNA Bind
Pairwise method
KEGG
Intrabursa
PDBeMotif
Co-immunoprecipitation
Predict Protein
Page 2 of 2
SLR-E-26
Section II
Q.2 Explain in detail Protein- DNA and Protein-Lipid interaction. Add note on their
detection methods.
14
Q.3 Explain in detail the ADMET properties with their significance in lead
identification.
14
Q.4 Explain the CATH SCOP structural classification database in detail and a note
on protein folding in detail.
14
Q.5 Answer any two of the following: 14
Write a note on Pharmacodynamics.
Write a note on identification of drug target.
What are structural Bioinformatics? Explain Protein data bank and mmCIF file
format.
Q.6 Write short notes on any TWO of the following. 14
RNA structure prediction methods.
Drug toxicity
Homology modeling process