M.Sc. (Semester III) Examination Nov/Dec-2018
Biotechnology
COMPUTATIONAL STRUCTURE BIOLOGY AND DRUG DESIGNING
Time: 2½ Hours Max. Marks: 70
Instructions: All questions are compulsory.
Figures to right indicate full marks.
Q.1 Multiple choice questions 14
Catalytic residue annotation for enzymes are predicted using
database.
Literature BLAST
CAS PDB
Intra molecular protein-protein interaction prediction database is
DIP STRING
MINT BMID
Alpha helices are amino acid per helical turn.
4.5 2.3
3.6 1.8
Molecular chemical properties can be predicted using tools.
Chemtool Molinspiration
KEGG Draw JMol
Drugs are approved by
FAD FDD
FDA FAAD
is drug metabolizing enzymes.
Protease CYP2A
Kinase Amylase
The first generation secondary structure prediction method
Chou-Fasman PSI PRED
PHD All
Conserved pattern of amino acids in protein is called
Domain Motif
Structure Loop
is a method of protein modeling which is used to model those
proteins that do not have homologous proteins with known structure.
Helix prediction Protein prediction
Protein threading Secondary structure prediction
10) Relationships chemical structure and pharmacological activity in a
quantitative manner can be predicted by
QSAR PSAR
RSAR GSAR
11) The RCSB protein data bank is updated on
Daily Weekly
Monthly Yearly
Page 2 of 2
SLR-VW-26
12) Drugs combine with receptor and elicit appropriate response are called

Antagonist Agonist
Affinity Efficacy
13) Query sequence identity to template is selected to build 3D
structure.
>20 >25
>30 >15
14) Model can be evaluating by
Quality check WHAT IF
ANOVA ModEve
Q.2 Answer the following (any four) 08
What is Ramachandran Plot?
What is High Throughput Screening?
What is chemo-informatics?
What are lectins?
What are Coils?
Write a notes on (any two) 06
Write a note pharmacodynamics
Write a note Position specific scoring matrices
Write a note on PDBeFold
Q.3 Answer the following (any two) 08
Describe RNA structure prediction.
Describe protein DNA interaction.
Give account on ligand based drug design methods
Answer the following (any one) 06
Describe PDBeMotiff
Describe neural network method
Q.4 Answer the following (any two) 10
Give detailed account on fold recognition and threading.
Give detailed account on protein-ligand interaction.
Give account on biological pathway databases.
Answer the following (any one) 04
Describe combinatorial chemistry for preparation of drug library.
Describe the SCOP database.
Q.5 Answer the following (any two) 14
Explain in detail in silico ADMET properties.
Explain in detail protein-protein interaction.
What is homology modeling? Explain the steps of homology modeling.