FINAL EXAM NATIONAL BOARD OF EXAMINATIONS
DECEMBER 2016

POSSESSION USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE
EXAMINATION HALL.
HEMATOLOGY
PAPER I
HEMAT/D/16/48/I
Time 3 hours
Max. Marks 100
Important instructions:
• Attempt all questions in order.
• Each question carries 10 marks.
• Read the question carefully and answer to the point neatly and legibly.
• Do not leave any blank pages between two answers.
• Indicate the question number correctly for the answer in the margin space.
• Answer all the parts of a single question together.
• Start the answer to a question on a fresh page or leave adequate space between two answers.
• Draw table/diagrams/flowcharts wherever appropriate.
Write short notes on:
1. Regarding stem cells:
What is a Niche?
What are the types?
How are they regulated?
How are they mobilized?
What are the approved uses?

2. What are HIV associated lymphomas?
What are the factors in consideration for treatment of HIV
associated lymphomas?
How will you manage a case of primary CNS lymphoma?

3. In hemophilia:
How do you measure inhibitors?
What are the risk factors?
How do you treat inhibitors?
What are the newer treatment options?

4. What is Pegylated G-CSF?
What are other Pegylated products used in Hematology?
Prolonging half life of Factor VIII and their benefit.

5. What are the molecular subtypes of Diffuse Large B-Cell
Lymphoma
How do the clinical and molecular features of lymphomas
affect decision making in treatment?
3+7
6. What changes occur in RBC on storage?
What is the Hb threshold for blood transfusion?
What are outcomes with fresh vs old blood transfusion?
What are the complications of multiple RBC transfusions?

P.T.O.
FINAL EXAM NATIONAL BOARD OF EXAMINATIONS
DECEMBER 2016

POSSESSION USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE
EXAMINATION HALL.
HEMATOLOGY
PAPER I
7. What is the difference between a longitudinal and a cross
sectional study with examples in Hematology?
How do you interpret Kaplan Meier curve?
What is meant by strength of evidence and quantity of
evidence?

8. In personalised Hematology:
What is epigenetics?
Gene conversion problems.
Next generation DNA sequencing
Pharmacogenomics.

9. a What is the role of all-trans retinoic acid arsenic
trioxide chemotherapy in the management of acute
promelocytic leukemia
What are the risk factors of differentiation syndrome?

10. Central venous catheters used in leukemia patients:
Types of catheters.
Special precautions in inserting them.
Strategies for prevention of catheter malfunction.