FINAL EXAM NATIONAL BOARD OF EXAMINATIONS
JUNE 2017

POSSESSION USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE
EXAMINATION HALL.
HEMATOLOGY
PAPER I
HEMAT/J/17/48/I
Time 3 hours
Max. Marks 100
Important instructions:
• Attempt all questions in order.
• Each question carries 10 marks.
• Read the question carefully and answer to the point neatly and legibly.
• Do not leave any blank pages between two answers.
• Indicate the question number correctly for the answer in the margin space.
• Answer all the parts of a single question together.
• Start the answer to a question on a fresh page or leave adequate space between two answers.
• Draw table/diagrams/flowcharts wherever appropriate.
Write short notes on:
1. Iron homeostasis in human body:
How is normal iron homeostasis maintained?
Role of mutations affecting iron metabolism.
Clinical and laboratory diagnosis of iron deficiency.

2. Imatinib resistance in CML:
How is it diagnosed?
What are the causes?
What treatment options exist?

3. Febrile neutropenia:
What is febrile neutropenia?
How is it risk stratified?
How is it managed?

4. CART cells:
What are CART cells and how are they generated?
What is their therapeutic use in management of
hematological disorders
4+6
5. Anemia of chronic disease:
What are the causes?
How is it diagnosed?
How is it managed?

6. Amyloidosis:
What are the causes?
How is it diagnosed?
What is the management of light chain amyloidosis?

7. Research methodology:
Calculation of sample size in a research proposal.
Declaration of Helsinki.
Informed consent.

P.T.O.
FINAL EXAM NATIONAL BOARD OF EXAMINATIONS
JUNE 2017

POSSESSION USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE
EXAMINATION HALL.
HEMATOLOGY
PAPER I
8. JAK STAT signaling pathways:
What are the normal roles of JAK STAT pathways?
How are they altered and their role in CMPD?
How are patients with JAK mutation managed?

9. Hemophagocytic lymphohistiocytosis:
How does the patient present?
What are the causes?
Diagnostic criteria
Management

10. Bleeding disorders:
Laboratory evaluation of a patient suspected to have a
bleeding disorder.
Role of thromboelastography.
Modifiers of bleeding in Hemophilia A.