FINAL EXAM NATIONAL BOARD OF EXAMINATIONS
JUNE 2018

POSSESSION/USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE EXAMINATION HALL.
HEMATOLOGY
PAPER-I
HEMAT/J/18/48/I
Time: 3 hours
Max. Marks:100
IMPORTANT INSTRUCTIONS
Attempt all questions in order.
Each question carries 10 marks.
Read the question carefully and answer to the point neatly and legibly.
Do not leave any blank pages between two answers.
Indicate the question number correctly for the answer in the margin space
Answer all the parts of a single question together.
Start the answer to a question on a fresh page or leave adequate space between two answers.
Draw table/diagrams/flowcharts wherever appropriate.
Write short notes on:
1. Briefly outline iron metabolism.
Write about the role of hepcidin in iron absorption.
Clinical presentation of hereditary hemochromatosis.
Genetic basis of hereditary hemochromatosis

2. Red cell membrane disorders:
Pathogenesis
Diagnostic algorithm of investigations.
Management of these disorders.

3. Automated blood cell counters:
Describe the principle of the instruments.
What are the advantages of automation?
What are the difficulties encountered for accurate platelet
counts?

4. Epstein Barr virus infection:
Associated hematological conditions.
How should monitoring and management be done in a
patient with active clinical infection?
5+5
5. Hematologic clonal disorders:
How can clonality be established?
Describe conditions associated with benign proliferations
of large granular lymphocytes.
5+5
6. Inherited bleeding disorders:
Enumerate common clinical conditions encountered.
Investigations to be carried out in such a patient.
Which are the clinical conditions where the screening
coagulogram is normal?

7. Polycythemia in a 30-year-old male:
Describe the diagnostic approach.
Which are the hematological conditions which need to be
considered?
5+5
P.T.O.
FINAL EXAM NATIONAL BOARD OF EXAMINATIONS
JUNE 2018

POSSESSION/USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE EXAMINATION HALL.
8. Hydroxyurea therapy:
Describe the haematological conditions where it is used.
Mechanism of action in these situations.
5+5
9. Non transfusion dependent thalassemias:
Which are the conditions included?
How is iron overload managed in such patients?
5+5
10. HLA typing:
Describe the importance of HLA typing.
Which are the techniques being currently used?
What are the strategies adopted to find a compatible
match if no donor is available in the family?