FINAL EXAM NATIONAL BOARD OF EXAMINATIONS
DECEMBER 2017

POSSESSION/USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE EXAMINATION HALL.
HEMATOLOGY
PAPER-I
HEM/D/17/48/I
Time: 3 hours
Max. Marks: 100
• Attempt all questions in order.
• Each question carries 10 marks.
• Read the question carefully and answer to the point neatly and legibly.
• Do not leave any blank pages between two answers.
• Indicate the question number correctly for the answer in the margin space
• Answer all the parts of a single question together.
• Start the question to a question on a fresh page or leave adequate space between two answers.
• Draw table/diagrams/flowcharts wherever appropriate.
Write short notes on:
1. Vitamin B12 metabolism
Role of Vitamin B12 levels in diagnosis of B12
deficiency and pitfalls
Clinical manifestations of vitamin B12 deficiency
Non-megaloblastic macrocytic anemia and its causes

2. Hemophilia:
Causes of acquired hemophilia
Eliciting joint abnormalities
Prenatal diagnosis of hemophilia

3. Angiogenesis:
Its role in hematologic malignancies
Anti-angiogenic drugs in treatment of hematologic
malignancies
Markers of angiogenesis

4. AML:
Molecular markers affecting prognosis of AML
FLT3 Inhibitors
AML with related myelodysplasia

5. CART cells in Pediatric ALL:
Role of therapy in Pediatric ALL
How are they formed?
What lab facilities are required for generating and
using CART cells in patients?

6. Autoimmune hemolytic anemia
Management of warm type of AIHA.
Methods of detection of auto-antibodies against RBC
Coomb's negative auto immune hemolytic anemia

FINAL EXAM NATIONAL BOARD OF EXAMINATIONS
DECEMBER 2017

POSSESSION/USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE EXAMINATION HALL.
7. Compensation in clinical trials
Role of sponsors in clinical trial
Salient features of Phase II and III clinical trials.

8. Growth factors in normal hematopoiesis
Microenvironment in acquired aplastic anemia
Hematopoietic stem cell

9. Minimal residual disease in ALL:
What is minimal residual disease?
How is it detected?
How does treatment alter based on MRD?

10. What are T-reg cells and how are they picked up?
What is their role in ITP?
Describe in brief dendritic cells