B.Pharmacy (Semester Examination, 2017
PHARMACOLOGY I
Day and Date Saturday, 6-5-2017 Total Marks 80
Time 10.30 a.m. to 1.30 p.m.
Instructions Figures to right indicate full marks.
Mention main question and sub-question number correctly
for each of the answers.
Algorithms/charts may be drawn wherever necessary.
1. Choose the most appropriate alternative for following multiple choice questions .
(16×1=16)
Which of the following is a G-protein coupled receptor
Muscarinic cholinergic receptor Nicotinic cholinergic receptor
Glucocorticoid receptor Insulin receptor
An antagonist has
Intrinsic activity and no affinity
Only intrinsic activity and no affinity
No intrinsic activity and no affinity
Affinity same as agonist and devoid of intrinsic activity
Drugs interact with their receptors sites by forming
Ionic bonds Hydrogen bonds
Van der Waals bond All the above
Ocuserts are
Placed under the eyelid Intrauterine contraceptives
Monoclonal antibodies None of the above
Nitro-glycerine is given in angina pectoris by sublingual route because
Liver is by-passed Can be spat after desired effect
Rapid absorption All the above
The movement of drug molecules across the cell membrane is by
Diffusion through the lipid
Diffusing through aqueous pores that traverse the lipid
Combination with a carrier molecule which acts as a catalyst
All the above
The cardiac muscarinic receptors
Are of the M1 subtype
Are of the M2 subtype
Are selectively blocked by pirenzepine
Function through the PIP2 → IP3/DAG pathway
Yohimbine is an antagonist of receptors.
α1 α2
both a and b None of the above
Centrally acting skeletal muscle relaxant is
Carisoprodol Dantrolene Gallamine Succinylcholine
10) Muscarinic receptors are G-protein coupled receptors, causing
Inactivation of phospholipase C
Activation of adenylyl cyclase
Activation of potassium or inhibition of calcium channels
All of the above
11) β1 receptors are present in
Liver Kidney
Brain None of the above
12) Following is a naturally occurring tertiary amine anti-cholinesterase
Edrophonium Neostigmine
Pyridostigmine Physostigmine
13) The site of action of d-tubocurarine is
Spinal internuncial neurone
Motor nerve ending
Muscle end-plate
Sodium channels in the muscle fibre
14) Two drugs binding to the same receptors is
Chemical antagonism Pharmacokinetic antagonism
Competitive antagonism Non-competitive antagonism
15) Bio-transformation of the drugs is to render them
Less lipid soluble More protein bound
Less ionized Less protein bound
16) High plasma protein binding
Increases the volume of distribution of the drug
Facilities glomerular filtration of the drug
Minimizes drug interactions
Generally makes the drug long acting
2. Answer any four
Define agonist, antagonist, inverse agonist and competitive antagonist.
Write a note on excretion of drug.
What are the limitations of oral route of drug administration
Discuss pharmacology of Adrenergic Drugs.
Describe the structure and function of biological membrane with the help of an
illustrative diagram.
What is first pass metabolism Explain with example.
3. Answer the following (any two)
Discuss in detail the factor modifying drug absorption.
Define the term Receptor. Enlist receptor types. Explain in detail G-protein
coupled receptor.
Classify with examples the sympathomimetic (adrenergic drugs). Write a note
on pharmacological actions of adrenaline and noradrenaline.
4. Answer any four
Classify skeletal muscle relaxants and give their uses.
Give classification of cholinergic drugs with examples.
Give the mechanism of action and adverse effects of d-tubocurarine.
Give the muscarinic action of acetylcholine on heart and various smooth
muscles.
Write a note on Synergism and Antagonism
Discuss in brief drug toxicity in man.
5. Answer any two
Classify Adrenolytics. Name the different adrenergic receptor and their
distribution.
Discuss the pharmacological actions and toxicity of Atropine.
Discuss in detail dose response relationship and therapeutic Index.