B. Pharmacy (Semester (CGPA) Examination, 2018
pharmacology I
Day and Date Tuesday, 15-5-2018 Max. Marks 70
Time 10.30 a.m. to 1.30 p.m.
1. Multiple Choice Questions. (1×15=15)
Therapeutic Index is calculated as
ED/LD LD/ED
ED50/LD50 LD50/ED50
Physiological antagonist
has affinity and intrinsic activity
has affinity but no intrinsic activity
has neither affinity nor intrinsic activity
produces opposite pharmacological effects
deals with the study of drugs upon microorganisms and parasites living and multiplying in a living organism.
Microtherapy Chemotherapy
Pharmacotherapeutics Pharmacodynamics
Essential drugs are selected considering their
relevance to public health safety and efficacy
comparative cost effectiveness all the three
The pressor response of adrenaline is reversed to depressor response in Dale's vasomotor reversal by Dihydroergotamine which is
a Beta1 blocker a Beta2 blocker
an Alpha blocker both alpha and beta blocker
Cyproheptadine is an antagonist of
only serotonin only acetylcholine
only histamine all the three
Vasodilatation of vascular smooth muscle produced by 'epinephrine' is mediated via
B1 receptor B2 receptor
α1 receptor α2 receptor
is not a cholinomimetic natural alkaloid.
Arecholine Pilocarpine
Muscarine Methacholine
is a/are nasal decongestant(s).
Phenylephrine Xylometazoline
Phenyl propanolamine All the three
10) Adrenaline is coadministered with local anesthetics because,
adrenaline increases BP
Local anesthetics prolong the adrenaline activity
LAs are toxic
Adrenaline prolongs the local anesthetic activity
11) is an agent which has affinity and intrinsic activity.
Ligand Agonist
Antagonist Inverse agonist
12) Histamine is present in
Mast cells Brain cells
Both A and B Neither A nor B
13) Which of the route of administration gives 100% bioavailability
intravenous sublingual inhalation oral
14) Drugs that cause bronchodilator include all of the following except
Theophylline Ephedrine
Cromolyn Ipratropium bromide
15) Angiotensin II is not involved in
insulin release maintainance of BP
aldosterone release electrolyte balance
2. Solve any five
Write a note on essential drug concept.
Define receptor. Enlist different receptor families.
Classify adrenergic neurone blockers with examples.
What do you mean by the terms pharmacokinetics, antagonist, prodrug, side effects and duration of action
Give the physiological role of Leukotrienes and Platelet Activating factor.
Discuss neurohumoral trarnsmission at sympathetic, post ganglionic nerve endings.
3. Solve any three (10×3=30)
Discuss in detail drug toxicity in man.
Explain the term pharmacodynamics. Discuss the mechanisms of drug action and enlist the factors modifying drug action.
What is organophosphorus compound poisoning Discuss in detail the symptoms, care and its treatment.
Classify antihistaminic drugs and give their pharmacology.