B.Pharmacy (Semester Examination, 2017
(New CGPA)
PHARMACOLOGY I
Day and Date Tuesday, 16-5-2017 Total Marks 70
Time 10.30 a.m. to 1.30 p.m.
Instructions Figures to right indicate full marks.
Mention question and sub-question number compulsorily.
Appropriate charts/illustrations/algorithms may be drawn
whenever necessary.
I. Choose most appropriate alternative for following MCQs. (15×1=15)
The route of choice used for administration of bulk volume preparations
is
Oral Topical
Intravenous Intra-arterial
route should be avoided in shock due to local vasoconstriction
and delayed absorption.
Intrathecal Intravenous
Subcutaneous Oral
Which of the following drug acts by virtue of its Osmotic Activity
Magnesium Sulfate Mannitol
Lactulose All of these
When two concurrently administered drugs produce their effects in same
direction and total effect produced is summation of effects of individual drugs,
it is termed as
Additive Effect Synergism
Tachyphylaxis Antagonism
Downregulation of receptors can occur as a consequence of
Continuous use of agonists
Continuous use of antagonists
Denervation
Continuous use of CNS depressant
A teratogenic action is
Toxic action on liver Toxic action on fetus
Toxic action on blood Toxic action on kidneys
of the following is a prostaglandin analogue used in treatment
of peptic ulcer disease.
Anakinra Montelukast
Misoprostol Pirenzepine
'GPCRs are composed of transmembrane α-Helices traversing the membrane
times.
4 5 6 7
Which of the following possess intra-cellular or nuclear receptors
Catecholamines Prostaglandins
Steroid Hormones Kinins
10) Mast cell degranulation and histamine release takes place by
interaction on their surface.
IgA Antigen IgE Antigen
IgG Antigen IgM Antigen
11) An alpha blocker useful in benign prostate hyperplasia and associated urine
retention is
Prazosin Phenoxybenzamine
Phentolamine Tamsulosin
12) A typical side effect of Atropine like drugs is
Salivation Dryness of Mouth
Hearing impairment Myelosuppression
13) Carbamates like are irreversible inhibitors of acetylcholine
esterase.
Neostigmine Galantamine
OPC Insecticides Tacrine
14) Cardiac arrhythmias and arrest can occur especially with concurrent use of
and
Adrenaline and Lidocaine
Succinylcholine and Digitalis
Salbutamol and Ambroxol
Chlorpheniramine and Phenylehrine
15) is an example of anti-5-HT antiemetic drug blocking 5-HT3,
receptors.
Methylsergide Ondansetron
Metoclopramide Promethazine
II. Answer any five of the following
Which is the route of choice for administering drugs in children Justify with
advantages.
Define Ganglionic Blockers. Classify them with appropriate examples.
Define and explain hypersensitivity and Idiosyncrasy.
Write clinical applications of prostaglandin analogues.
Define Agonist, Antagonist, Partial Agonist and Inverse Agonist on the basis of
two-state receptor hypothesis.
Classify Acetylcholine Esterase Inhibitors. Explain the utility of Acetylcholine
Esterase Inhibitors in Myasthenia Gravis.
III. Answer any three of the following (3×10=30)
What are Anticholinergic drugs Classify them with examples. Elaborate
pharmacology of Atropine in brief.
Define antihistaminic drugs. Enlist their classes with examples. Write
pharmacological account of antihistaminic drugs.
Define 'Drug Receptors'. Summarize Families and second messenger
mechanisms of G Protein Coupled Receptors.
Enumerate alpha blockers in a classified manner. Write pharmacological actions,
adverse effects and uses of alpha blockers.