B.Pharmacy (Semester Examination, 2018
Pharmacology I (CBCS Pattern)
Day and Date Tuesday, 18-12-2018 Max. Marks 70
Time 10.30 a.m. to 1.30 p.m.
1. Multiple Choice Question (1×15=15)
What is characteristic of the oral route
Fast onset of effect
Absorption depends on GI tract secretion and motor function
A drug reaches the blood passing the liver
The sterilization of medicinal forms is obligatory
Half life doesn't depend on
Biotransformation
Time of Drug Absorption
Concentration of a drug in plasma
Rate of drug elimination
The mechanism of atropine action is
Competitive ganglion blockade
Competitive muscarinic blockade
Competitive neuromuscular blockade
Noncompetitive neuromuscular blockade
Acetylcholine is not used in clinical practice because
It is very toxic
The doses required are very high
It is very rapidly hydrolyzed
It is very costly
P.T.O.
Set P Seat
No.
Set P
SLR-TV 35 *SLRTV35*
β1 receptor is present in
Adipose tissue Bronchi
Heart All of the above
Which of the following sympathomimetics acts indirectly
Epinephrine Norepinephrine
Ephedrine Methoxamine
Antimuscarinics are used in the treatment of the following disorders except
Motion Sickness Glaucoma
Hyperhidrosis Asthma
the substance which changes the activity of an effector element
but doesn't belong to second messengers
cAMP cGMP G-protein Calcium ions
The therapeutic index of a drug is a measure of its
Safety Potency
Efficacy Dose Variability
10) Indicate the alpha2 selective agonist
Phentolamine Dihydroergotamine
Clonidine Labetalol
11) Which of the following effects is associated with beta3-receptor stimulation
Lipolysis Decrease in platelet aggregation
Bronchodilation Tachycardia
12) Aggregation of platelet is promoted by the
Prostaglandin Prostacyclin
Thromboxane Both option and
13) 5-HT appears to play a role in the following except
Regulation of Normal BP
Regulation of Intestinal peristalsis
Haemostasis
Causation of migraine
14) Which is prostaglandin analogue
Pirenzepine Hyoscine
Latanoprost Norepinephrine
15) Which of the following eicoasanoids is Ulcer Protective
PGI2 TXA2 LTB4 LTC4
Set P
2. Answer any five of the following
Discuss about Adrenergic receptor, their Sites, Agonist, and Antagonist.
Write in brief about Nature and Sources of Drug.
List out unique advantages and disadvantages of oral and parental route
of Administration.
Write short notes on Ganglionic blockers and Ganglionic stimulants.
Classify skeletal muscle relaxants. Give their uses.
Give the muscarinic action of acetylcholine on heart and various smooth
muscles
3. Answer any three of the following (3×10=30)
What are autacoids Write the Synthesis, Pharmacological action and
Pathophysiological role of 5-HT.
Classify Adrenolytics with examples. Discuss in details pharmacology of
α-adrenergic blocker.
Classify H1 antagonist with suitable examples. Explain mechanisms
of action, pharmacological action, adverse effects, therapeutic uses of
antihistaminic.
Classify Anticholinergic drugs with example. Discuss in detail pharmacology
of Atropine