Master of Science II(Bioinformatics)
Examination: Oct/Nov 2016 Semester III (New CBCS)
SLR No. Day
Date Time Subject Name Paper
No. Seat No.
SLR SR-
82
Monday
21/11/2016
02:30 P.M
to
05:00 P.M
Computational
Structure Biology and
Drug Designing
C
XI
Instructions: Part Question 1 is compulsory.
Attempt any four questions from Part II.
Attempt to the Part I and Part II are to be written in same
answer book.
Figures to the right indicate full marks.
Total Marks: 70
PART I
Q.1 Rewrite the following sentences by selecting correct answers from given
alternative.
07
Homology modeling is also called as modeling.
Comparative Secondary
Primary Domain
Proteomics is the study of
Set of proteins in a specific region of the cell
Set of proteins
Entire set of expressed proteins in a cell
None of these
Model can be evaluating by
Procheck ANOLEA
WHAT IF All of these
Protein-Protein interaction prediction databases are
DIP MINT
STRING All of these
is the method used to design the drug using the knowledge of 3D
structure of protein.
Ligand based drug design Structure based drug design
Both a and b None of these
visualization tool which does not recognize PDB format.
Cn3D RasMol
RasTop PyMol
Molecular chemical structures can be designed using
ACD Lab Chem sketch
KEGG draw All of these
Page 1 of 2
Definitions: 07
Prodrug
RCSB PDB
CYP450
SCOP
HTS
Domain
Lectin
PART II
Answer any four of the following:
Q.2 What is yeast two hybrid system? Explain the mechanism of yeast two hybrid
systems for predicting Protein-Protein interaction.
14
Q.3 Explain the Homology modeling with its steps in details and Give a detail account
on different programmes for the homology modeling.
14
Q.4 Explain the 3D structure prediction and explain fold recognition and threading
method in details.
14
Q.5 Answers any two from the following: 14
Write a note on combinatorial chemistry.
What is structural bioinformatics? Explain the RCSB PDB and mm CIF file
format in details.
Explain in detail the different phases of clinical trials.
Q.6 Write short notes on any two: 14
CATH and SCOP
PubChem
Protein-carbohydrate interaction