M.Sc. (Semester III) (CBCS) Examination Oct/Nov-2017
Bioinformatics
COMPUTATIONAL STRUCTURE BIOLOGY AND DRUG DESIGNING
Day Date: Tuesday, 21-11-2017 Max. Marks: 70
Time: 02.30 PM to 05.00 PM
Instructions: Part-1, Question 1 is compulsory.
Attempt any four questions from Part-II.
Figures to the right indicate full marks.
Answer to the Part-I and Part-II are to be written in same answer Booklet
only.
PART I
Q.1 Rewrite the sentence after choosing the correct answer from the
given alternatives:
07
is web based service for analysis, visualization and
validation of NMR structure.
NMR core NMRclust
Vivaldi VASCO
Drug metabolism takes place in
Liver Kidney
Brain All of these
MNT is
Protein database Pathway database
Interaction database All of these
display a schematic diagram of all interaction between
DNA and Protein.
Nuclpolt Thumbnail Image
Wiring Diagram Ligplot
is database of protein models generated by Modeller
Program.
ModBase 3D Crunch
PDB PDBsum
is drug designing tool.
Keg draw ACD lab
Chem. Sketch All of these
The 3D structure of Protein can be modeled
PSI PRED Swiss Model
GOR PHD
Page 2 of 2
SLR-MC-77
Definitions 07
Template.
Efficacy.
PDBeNMR.
Potency.
Jmol
QSPR.
Domain
PART II
Answer any four of the following
Q2 Explain in detail Protein-lipid and protein-DNA interaction with database and
applications.
14
Q3 Explain in detail in silico drug discovery process and challenges. 14
Q4 Explain RNA structures prediction method and a note on molecular
visualization software's.
14
Q5 Answer any two of the following 14
Write a note on QSAR and its applications.
Write a note on mutations in drug targets.
Write a note on structure visualization with tools.
Q6 Answer any two of the following 14
CATCH and SCOP.
Drug absorption.
Protein Folding.