M.Sc. (Semester III) (CBCS) Examination Nov/Dec-2018
Bioinformatics
COMPUTATIONAL STRUCTURE BIOLOGY AND DRUG DESIGNING
Time: 2½ Hours Max. Marks: 70
Instructions: All questions are compulsory
Figures to the right indicate full marks.
Q.1 Multiple choice Questions:- 14
is web based service for analysis, visualization and validation
of NMR structure.
Vivaldi Olderado
Nmrcore Nmrclust
Metabolism of an oral drug via the liver is called
First pass metabolism Second pass metabolism
Last pass metabolism Drug pass metabolism
The secondary structure is stabilized by hydrogen bonds between residue I

i+5 i+7
i+4 i+2
Polar surface area of drug should be
<120 Ao <140 Ao
<150 Ao <200 Ao
is database of protein models generated by homology programme.
PDB CSA
Modbase 3D crunch
Drugs are approved by
FAD FDD
FDA FAAD
is a method of protein modeling which is used to model those
proteins that do not have homologous proteins with known structure.
Helix prediction Protein prediction
Protein threading Secondary structure
is the major drug metabolizing enzymes.
CYP2C19 CYP2A
CYP2D6 CYP450
The loop refers to a single stranded region connecting two
adjacent base paired segments to form bubbles.
Buldge Interior
Multibranch Hairpin
10) Pharmacologically inactive compounds are called
Prodrug Predrug
Postdrug Biodrug
Page 2 of 2
SLR-VC-58
11) SSAP automatic structural alignment programme classifies the protein in
database.
SCOP CATH
PDBsum PDBeFold
12) A single transmembrane is called
Peripheral membrane protein
Polytopic transmembrane
Bitopic membrane protein
Polytopic transmembrane protein
13) A pattern of DNA sequence that is similar for gene of similar function is
called
Motif Domain
Tunnels Pores
14) motif is the most commonly used secondary structure for specific
DNA recognition.
Beta-Helix-Beta Helix-Beta-Helix
Zinc Finger Ca Finger
Q.2. Answer any four of the following. 08
What is STRING DATABASE?
What is role of wwPDB database in protein data bank database?
What is nuclplot in pdbsumdatabase?
What is GRID?
What is interior loop in RNA structure prediction?
Write notes on. (Any Two) 06
Explain the biological pathway database in details.
Describe the consequences of drug target mutation.
Explain the development of lead library from lead compounds.
Q.3. Answer the following. (Any Two) 08
Explain PDBe Fold database in detail.
Explain the Lipnski rule of five in detail.
Explain the architecture of protein structure visualization in various
softwares.
Answer the following:- (Any One) 06
Explain the combinatorial chemistry in detail.
Explain the threading method for prediction protein three dimensional
structures.
Q.4. Answer the following. (Any Two) 10
Write in details about the Protein-DNA interaction with its tools.
Write in detail about pharmacodynamics.
Explain protein structure classification database in details.
Answer the following:- (Any One) 04
Explain the structure based drug designing in detail.
Explain the Chou-fasman secondary structure prediction method.
Q.5. Answer the following. (Any Two) 14
Write in details about the protein folding and challenges in bioinformatics.
Explain the different methods of drug target identification.
Explain the RCSB PDB database and protein data bank file format in details.