Seat No.: Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
PHARM.D YEAR-2 EXAMINATION SUMMER-2019
Subject Code: 828801 Date: 06/05/2019
Subject Name: Pathophysiology
Time: 10:30 AM TO 01:30 PM Total Marks: 70
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks
Q.1

Explain the mechanism of increased vascular permeability in acute inflammation.
06

Write a note on types of collagen and their significance.
04

Briefly describe Lymph node changes in leprosy.
04
Q.2

What is apoptosis? Explain in brief about molecular mechanism of apoptosis.
06

Discuss the difference between Necrosis and Gangrene.
04

Write a note on protein calorie malnutrition.
04
Q.3

Enumerate the types of hypersensitivity reactions. Write in detail about Type I (anaphylactic) hypersensitivity.
06

Discuss the pathogenesis and clinical manifestations of AIDS.
04

Enlist environmental pollutants. Write short note on carbon monoxide.
04
Q.4

Discuss mechanism of metastasis and outline the role of stroma in tumor progression.
06

Discuss pathology of chronic passive congestion.
04

Discuss pathogenesis and pathology of alcoholic liver disease.
04
Q.5

Define and classify amyloidosis. Explain the pathogenesis and clinical manifestations of senile cardiac amyloidosis.
06

Briefly explain the Pathogenesis of cerebral malaria.
04

Explain the mechanism of allograft rejection.
04
Q. 6

Discuss mechanisms involved in tissue repair. Add a note on Factors affecting wound healing.
06

Write the pathophysiology of Septic shock.
04

Write a note on Obesity associated disease.
04
Q.7

Discuss the pathogenesis, clinical manifestations and diagnosis of COPD?
06

Classify diabetes mellitus and describe pathology of pancreas in it.
04

Describe the pathogenesis, clinical manifestations of Parkinson's disease.
04