Page 1 of 3
Seat No.: Enrolment
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM SEMESTER EXAMINATION -WINTER 2018
Subject Code: BP304TT Date: 10/12/2018
Subject Name: Pathophysiology
Time: 10:30 AM TO 01:30 PM Total Marks: 80
Instructions:
1. Attempt five questions.
2. Make Suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1
Choose correct option for following questions
16
1
2
3
4
5
6
7
8
9
10
Find out the correct statement with regards to tuberculosis:
Mycobacterium tuberculosis is a facultative aerobic organism
Primary infection of tuberculosis is in GI tract
It represents granulomatous inflammation
Type of cell death in tuberculosis is apoptosis
Find out pair of major phagocytes of blood:
Monocyte, Neutrophils Lymphocyte, Neutrophils
Basophil, Eiosinophil Lymphocyte, Monocyte
Which of the following gland undergoes physiological atrophy with increase in age?
Thymus Adrenal gland
Spleen Pituitary gland
Expression of pro-apoptotic molecules is a novel target for treatment of:
Diabetes Alzheimer's disease
AIDS Cancer
Find out arachidonic acid metabolite which induces platelet aggregation
Thromboxane A2 Histamine
Prostaglandin I2 Serotonin
Formation of uric acid crystals in synovial joints resulting in inflammation of synovial joints is known as:
Osteoarthritis Rheumatism
Gouty arthritis Spondylitis
Peptic ulcer is due to infection of:
Helicobacter pylori infection in ileum
Helicobacter pylori infection in pylorus
Entamoebica histolytica infection in ileum
Entamoebica histolytica infection in pylorus
Carcinoma refers to cancer of:
Epithelial tissue Nervous tissue
Connective tissue Muscular tissue
Widal test is used for diagnosis for:
Syphilis Gonorrhoea
Typhoid AIDS
Commonly observed bone disorder in menopause is:
Rickets Osteomalacia
Page 2 of 3
11
12
13
14
15
16
Osteomyelitis Osteoporosis
Hemophilia-A occurs due to deficiency of:
Clotting factor XII Clotting factor VII
Clotting factor VIII Clotting factor V
Pulmonary edema is commonly observed complication in:
Essential hypertension Congestive cardiac failure
Secondary hypertension Megaloblastic anaemia
Hyperkalaemia can be observed due to:
Hyperaldosteronism Cushing's syndrome
Excess insulin therapy Addison's disease
Epilepsy may result in convulsions when neuronal firing increases in
Medulla oblongata Midbrain
Motor cortex Cerebellum
Diabetes insipidus refers to:
Sodium and water retention
Increased urine formation due to deficiency of aldosterone
Increased urine formation due to increase in urine sugar
Increased urine formation due to deficiency of anti-diuretic hormone
Find out the correct statement with regards to urinary tract infection:
Upper urinary tract infections are more common as compare to lower urinary tract infections.
Urinary tract infections are more common in female as compared to male.
Major causative organisms of urinary tract infection are gram positive in nature.
Diuresis is a commonly observed symptom of urinary tract infection.
Q.2

Enlist hereditary anaemia. Add a note on sickle cell anaemia.
06

Compare and contrast: Type 1 and Type 2 diabetes mellitus. Write complications of diabetes in brief.
05

Describe pathogenesis of congestive cardiac failure.
05
Q.3

Explain following terms: Homeostasis Negative feedback system
Metaplasia
06

Describe pathogenesis of cancer in brief.
05

What is angina pectoris? Classify it. Discuss pathogenesis of angina pectoris in brief.
05
Q.4

Give comment on:
Hypertension is a silent killer.
Vitamin B12 deficiency is referred as megaloblastic anaemia.
Schizophrenia is a neurodevelopmental disorder.
06

Define inflammation. Describe cellular events of acute inflammation in detail.
05

Describe pathogenesis, symptoms and complications for acute renal failure.
05
Q.5

Draw life cycle of HIV virus. Discuss diagnosis, symptoms and pathogenesis of AIDS.
06

Enlist various types of hepatitis. Discuss etiology, symptoms and complications of hepatitis A.
05

Describe etiology and pathogenesis of rheumatoid arthritis.
05
Q. 6

Write symptoms for following disease:
Cretinism Depression Inflammatory bowel disease
06
Page 3 of 3

Explain the processes involved in healing of skin wounds in brief.
05

Discuss symptoms and pathogenesis of COPD.
05
Q.7

Enlist various factors leading to cell injury. Discuss reversible cell injury due to ischaemia.
06

Define apoptosis. Write in detail about mechanism of apoptosis.
05

Enlist neurodegenerative diseases. Write neurochemistry and symptoms of Parkinson's disease.
05