Seat No.: Enrolment
GUJARAT TECHNOLOGICAL UNIVERSITY
B.Pharm SEMESTER- III • EXAMINATION SUMMER 2017
Subject code: 230005 Date: 09/06/2017
Subject Name: Pathophysiology
Time: 02:30 PM to 05:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

What is Inflammation? Explain chemical mediators of inflammation.
06

Describe process of apoptosis. Explain its significance.
05

Describe biological effects of radiation.
05
Q.2

What is cellular adaptation? Differentiate between atrophy and hypertrophy.
06

Enlist components of extracellular matrix. Describe its significance.
05

What is autoimmunity? Write a note on Rheumatoid arthritis.
05
Q.3

Write short note on
1. Systemic Lupus Erythematosus
2. AIDS
06

Explain in detail mechanism of allograft rejection.
05

Discuss etiology and pathogenesis of fatty liver.
05
Q.4

Explain the terms
1. Hyperplasia
2. Necrosis
06

What is hypersensitivity reaction? Explain different types of hypersensitivity reactions.
05

Differentiate between Marasmus and Kwashiorkor.
05
Q.5

Describe cellular and molecular mechanism of cell injury due to ischemia.
06

Explain the process of wound healing by secondary union.
05

Discuss pathogenesis of Nutritional Deficiency Diseases.
05
Q. 6

Write note on
1. Amyloidosis
2. Protein energy malnutrition
06

Explain the HLA system and major histocompatibility complex.
05

What are abnormal intracellular accumulations? Explain pathological conditions associated with excessive accumulation of intracellular glycogen.
05
Q. 7

Write note on
1. Environmental pollutants
2. Calcification
06

What is obesity? Discuss etiology and metabolic changes associated with obesity.
05

Write a note on growth factors involved in tissue repair.
05