Exam Details
| Subject | dosage form design –i | |
| Paper | ||
| Exam / Course | b.pharm | |
| Department | ||
| Organization | Gujarat Technological University | |
| Position | ||
| Exam Date | November, 2018 | |
| City, State | gujarat, ahmedabad |
Question Paper
Seat No.: Enrolment
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM SEMESTER EXAMINATION -WINTER 2018
Subject Code: 2270001 Date: 15/11/2018
Subject Name: Dosage form Design I
Time: 10:30 AM TO 01:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make Suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1
Define Preformulation studies. Explain steps involved in Preformulation studies.
06
How polymorphism and crystallinity influence performance of drug product. Explain in brief methods to identify polymorphism and crystallinity.
05
Define diluents. Classify Diluents. Write a note on versatility of lactose as diluents in oral solid dosage forms.
05
Q.2
Define disintegrating agent. Give examples of commonly used disintegrating agents. Write mechanism of disintegration.
06
What do you mean by polymer? Write a note on polymers used in different dosage forms with examples.
05
Write short note on passive diffusion.
05
Q.3
Write a note on Prodrug. Discuss Prodrug approaches.
06
Write a short note on Matrixing and Bracketing study design.
05
Define bioequivalence. Write a short note on Latin-square cross-over design.
05
Q.4
Write a note on factors affecting on stability of pharmaceutical dosage form.
06
Discuss in detail volume of distribution.
05
How purity of API and drug degradation are studied in product development?
05
Q.5
Discuss Noyes Whitney equation for rate of dissolution. Discuss USP type I apparatus for dissolution.
06
Define overages and discuss methods to determine overages.
05
Discuss remedies to overcome degradation due to hydrolysis and oxidation in pharmaceutical dosage form.
05
Q. 6
Define biopharmaceutics. Enlist various mechanisms of drug transport. Discus active transport in detail.
06
Draw a well labelled diagram of cell membrane and Discuss Endocytosis.
05
Define relative and absolute bioavailability. Discuss plasma level time studies for measurement of bioavailability.
05
Q.7
Write a short note on "Plasma Protein Binding"
06
Discuss tissue permeability of drug in distribution.
05
Write a note on drug clearance.
05
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM SEMESTER EXAMINATION -WINTER 2018
Subject Code: 2270001 Date: 15/11/2018
Subject Name: Dosage form Design I
Time: 10:30 AM TO 01:30 PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make Suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1
Define Preformulation studies. Explain steps involved in Preformulation studies.
06
How polymorphism and crystallinity influence performance of drug product. Explain in brief methods to identify polymorphism and crystallinity.
05
Define diluents. Classify Diluents. Write a note on versatility of lactose as diluents in oral solid dosage forms.
05
Q.2
Define disintegrating agent. Give examples of commonly used disintegrating agents. Write mechanism of disintegration.
06
What do you mean by polymer? Write a note on polymers used in different dosage forms with examples.
05
Write short note on passive diffusion.
05
Q.3
Write a note on Prodrug. Discuss Prodrug approaches.
06
Write a short note on Matrixing and Bracketing study design.
05
Define bioequivalence. Write a short note on Latin-square cross-over design.
05
Q.4
Write a note on factors affecting on stability of pharmaceutical dosage form.
06
Discuss in detail volume of distribution.
05
How purity of API and drug degradation are studied in product development?
05
Q.5
Discuss Noyes Whitney equation for rate of dissolution. Discuss USP type I apparatus for dissolution.
06
Define overages and discuss methods to determine overages.
05
Discuss remedies to overcome degradation due to hydrolysis and oxidation in pharmaceutical dosage form.
05
Q. 6
Define biopharmaceutics. Enlist various mechanisms of drug transport. Discus active transport in detail.
06
Draw a well labelled diagram of cell membrane and Discuss Endocytosis.
05
Define relative and absolute bioavailability. Discuss plasma level time studies for measurement of bioavailability.
05
Q.7
Write a short note on "Plasma Protein Binding"
06
Discuss tissue permeability of drug in distribution.
05
Write a note on drug clearance.
05
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- agronomy and forestry of medicinal plants
- anatomy physiology & health education -ii
- anatomy, physiology and health education (aphe)
- applied mathematics (biostatistics)
- basic computer applications
- basic concepts of pharmacology and clinical pharmacy practice
- basics of computer applications
- bioavailability & therapeutic drug monitoring
- bioavailability and therapeutic drug monitoring
- biochemistry
- clinical pharmacy ii
- clinical pharmacy-i
- commerce of herbs and phytoconstitutents
- computer applications in drug discovery
- current advances in novel drug delivery systems
- cyber security
- disaster management
- dispensing pharmacy i
- dispensing pharmacy i and drug store management
- dispensing pharmacy ii and pharma industrial management
- dosage form design –i
- dosage form design- i
- dosage form design- ii
- dosage form design-i
- dosage form design-ii
- drug approval process
- environmental studies
- environmental toxicology and green audit
- food analysis
- forensic pharmacy
- forensic pharmacy-i
- genetic engineering and gene therapy
- green chemistry
- health education and community health
- herbal cosmetics
- hospital and community pharmacy
- hospital management and medical tourism
- hospital pharmacy, community pharmacy & forensic pharmacy
- hospital pharmacy, community pharmacy and dispensing pharmacy-ii
- human anatomy physiology
- human anatomy physiology and health education-ii
- human anatomy physiology-ii
- human anatomy, physiology and health education - i
- innovations in conventional drug delivery system
- instrumental and process validation
- intellectual property rights and patents
- medical writing and coding
- medicinal biochemistry
- nutraceuticals
- pathophysiology
- pharmaceutical analysis ii
- pharmaceutical analysis iii
- pharmaceutical analysis iv
- pharmaceutical analysis-i
- pharmaceutical analysis-ii
- pharmaceutical analysis-iv
- pharmaceutical chemistry – ii
- pharmaceutical chemistry – vi (organic chemistry – ii)
- pharmaceutical chemistry –viii (medicinal chemistry - ii)
- pharmaceutical chemistry iii
- pharmaceutical chemistry iv
- pharmaceutical chemistry vii
- pharmaceutical chemistry-i
- pharmaceutical chemistry-i (inorganic chemistry)
- pharmaceutical chemistry-ii (physical chemistry)
- pharmaceutical chemistry-iii (biochemistry – i)
- pharmaceutical chemistry-iv (organic chemistry-i)
- pharmaceutical chemistry-ix (medicinal chemistry-iii)
- pharmaceutical chemistry-v
- pharmaceutical chemistry-v (biochemistry-ii)
- pharmaceutical chemistry-vi (medicinal)
- pharmaceutical chemistry-vii
- pharmaceutical chemistry-viii
- pharmaceutical chemistry-x
- pharmaceutical chemistry-x (medicinal chemistry-iii)
- pharmaceutical engineering
- pharmaceutical engineering-ii
- pharmaceutical inorganic chemistry
- pharmaceutical marketing management
- pharmaceutical microbiology - i
- pharmaceutical microbiology & biotechnology i
- pharmaceutical microbiology &biotechnology- ii
- pharmaceutical microbiology and biotechnology - ii
- pharmaceutical organic chemistry
- pharmaceutical technology - i
- pharmaceutical technology – i
- pharmaceutical technology- ii
- pharmaceutical technology-i
- pharmaceutical technology-ii
- pharmaceutics-i
- pharmaceutics-ii
- pharmaceutivcal chemistry ix
- pharmacognosy iii
- pharmacognosy iv
- pharmacognosy vi
- pharmacognosy vii
- pharmacognosy vii (herbal formulations & complimentary therapies)
- pharmacognosy-i
- pharmacognosy-ii
- pharmacognosy-iii
- pharmacognosy-iv
- pharmacognosy-v
- pharmacognosy-v (plant bio technology)
- pharmacognosy-vi
- pharmacology -iii
- pharmacology & pharmacotherapeutics-ii
- pharmacology and pharmacotherapeutics - i
- pharmacology and pharmacotherapeutics - iii
- pharmacology and pharmacotherapeutics-iv
- pharmacology-i
- pharmacology-ii
- pharmacovigilance
- pharmacy practice
- physical pharmaceutics-ii
- physical pharmacy
- quality by design (qbd) and process analytical technology (pat)
- regulatory aspects of food and neutraceuticals
- remedial mathematics
- unit operation - i
- unit operation - ii