Seat No.: Enrolment No.
GUJARAT TECHNOLOGICAL UNIVERSITY
B.Ph. SEMESTER-VII • EXAMINATION SUMMER- -2018
Subject Code: 2270001 Date: 19/05/2018
Subject Name: Dosage Form Design
Time: 02:30PM TO 05:30PM Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1

What is binder? Discuss the effect of binder on formulation of Pharmaceutical
product.
06

What is Disintegrant. Give the mechanism of and Factor affecting disintegrant
on formulation of pharmaceutical product.
05

Write a note on effect of emulsifying and suspending agent on Pharmaceutical
formulation.
05
Q.2

How does particle size influence GI absorption of drugs? Explain with suitable
example.
06

Writes the importance of physical forms in drug absorption. Explain with
suitable example.
05

Explain the characteristics of Active transport process. Write their application
in the development of formulation and administration of drugs.
05
Q.3

Define Preformulation? Give its importance.
06

Enumerate the drug degradation pathways and discuss Hydrolysis in detail.
05

Write notes on physicochemical parameters studied in preformulation study.
05
Q.4

Explain world climatic zones as per ICH guidelines.
06

Discuss Brackating and Matrixing in brief
05

Discuss the factors affecting stability of drug.
05
Q.5

What is BCS? Classify and give the significance of this system
06

Explain USP dissolution apparatus III, IV and V with diagram.
05

What is rvrvc? Describe In-vitro In-vivo correlations levels.
05
Q. 6

Write a note on similarity factor and dissimilarity factor.
06

Explain: Shelf life Overages Protein binding
05

Discuss pH —Partition hypothesis briefly with suitable examples. Enumerate the assumptions of this hypothesis.
05
Q.7

Give a brief account on any one method of determining the bioavaibility.
06

Write a short notes on Biodegradable polymers.
05

Enumerates factors affecting dissolution of drug, discuss factors related to drug
product formulation.
05