FACULTY OF PHARMACY
B. Pharmacy 3/4 I-Semester (Main) Examination, November 2016
Subject Physical Pharmacy I
Time 3 Hours Max. Marks: 70
Note: Answer all questions. All questions carry equal marks.
1 How do you liquefy gases? Write its application in the formulation of aerosols.
Define the terms refractive index and molar refraction. Write their applications.
OR
Write Gibb's phase rule. Explain phase diagram for a system containing one
component.
Write a short note on XRD.
Write the Vander Waals equation for real gases and explain the terms therein.
2 State and explain first law of thermodynamics.
State and explain second law of thermodynamics. Write its applications with
relevant equations and graphs.
OR
Define
Specific heat Latent heat Enthalpy entropy Sensible heat
State laws of thermodynamics.
Explain Hess's law with relevance to heat of formation and heat of combustion.
3 Define Raoults law. What are ideal and real solutions. (Explain with vapor pressure
curves).
Write the Debye Huckel's equations for determining activity coefficient.
What are ampholytes. Explain their ionization.
OR
How do you determine elevation of boiling point? Explain the choice of colligative
properties in molecular weight determination.
An aqueous solution of FeSO4 was prepared by adding 41.5 g of FeSO4 to enough
water to make 1000 ml. Density of solution 1.0375 mol. Wt of FeSO4 151.9.
Calculate Molarity Molality mole fraction of FeSO4 and water and
percentage by weight of FeSO4.
What is mean by ionic strength of a solution?
4 Derive Henderson Hassebach equation for a weak acid.
What is the pH of 0.1m acetic acid solution. PKa=4.76 What is the pH after
addition of 0.1m sodium acetate.
Describe the applications of pH and buffer solution with examples.
OR
Explain various methods to adjust isotonicity and pH.
Write a note on pH indicators.
Write the equation for buffer capacity.
5 Explain Daniell cell.
How do you determine PKa using potentiometry?
Explain any two oxidation reduction reaction in pharmacy.
OR
How do you determine pH using glass electrode?
Write a note on catalyst.