FACULTY OF PHARMACY
B. Pharmacy 3/4 I-Semester (Suppl.) Examination, April 2017
Subject Physical Pharmacy I
Time 3 Hours Max. Marks: 70
Note: Answer all questions. All questions carry equal marks.
1 State and explain Gibbs phase rule. Explain the phase diagram for one component
system.
Write about differential scanning calorimetry and its applications in pharmacy.
OR
Discuss about polymorphism and its applications in pharmacy.
State the postulates of kinetic molecular theory of gases and explain Vander-Walls
equation for real gases.
2 State and explain law of conservation of energy.
Derive expressions for isothermal reversible expansion of an ideal gas and
maximum work done in reversible expansion.
Write a note on Gibbs free energy.
OR
Explain specific heat, sensible heat and latent heat.
Define free energy. Write about free energy function and its applications.
3 What are colligative properties? Explain determination of freezing point depression
and its application.
Explain the importance of activity and activity coefficients.
OR
Define molarity, molality and normality. Explain in which situations these
expressions are useful.
Derive the equation for ionization of a weak acid and write about ampholytes.
4 Derive Henderson-Hassel balch buffer equation for a weak acid and its salt.
Write a note on pharmaceutical and physiological buffers.
OR
What is buffer capacity? Write the equations for buffer capacity and maximum buffer
capacity.
What is isotonicity? What are the various methods of adjusting isotonicity. A solution
contains 1.0g cphedrine sulphate in 100ml. What quantity of sodium chloride must
be added to make the solution isotonic (sodium chloride equivalent of ephedrine
sulphate is 0.23)..
5 Discuss the construction and working of a glass membrane electrode.
Write about the method of determining the emf of a cell using potentiometer.
OR
Mention various types of electrodes with examples including the cell reaction
representation.
Write about the importance of applications of oxidation reductions in pharmacy.