FACULTY OF PHARMACY
B. Pharmacy 3/4 I Semester (Main) Examination, November 2017
Subject Physical Pharmacy I
Time 3 hours Max. Marks 70
Note Answer all questions. All questions carry equal marks.
1 Explain polymorphism with examples. Write its significance. 7
Explain the phase diagram for a two component mixtures. 7
OR
Write a note on
Differential scanning calorimetry 7
ii) Liquid crystalline state 7
2 Explain law of conservation of energy and Hess's law of constant heat
summation. 8
Define, explain and write applications of heat of combustion and heat of
neutralization. 6
OR
Define and explain second law of thermodynamics. 7
Explain enthalpy and entropy. 7
3 State Raoults law. Explain positive and negative deviations of Raoults law. 7
Explain the application of any two colligative properties in molecular weight
determination. 7
OR
Explain Arrhenius theory of electrolyte dissociation and its limitations. 7
Explain ionization of polyprotic electrolytes. 7
4 What are buffers? Derive Henderson-Hasselbach equation for acidic buffer. 7
Explain cryoscopic method and sodium chloride equivalent method for
adjusting isotonicity. 7
OR
What is buffer capacity? Write Vanslyke's equation for buffer capacity and
maximum buffer capacity. 7
How do you prepare a pharmaceutical buffer? 7
5 Give the description and working of glass electrode. 10
Write the Nernst equation. 4
OR
Explain ion sensitive electrodes. 7
How do you determine pKa using potentiometry? 7