B.Pharmacy (Semester VIII) Examination, 2017
PHARMACEUTICAL ANALYSIS VI
Day and Date Monday, 15-5-2017 Total Marks 80
Time 3.00 p.m. to 6.00 p.m.
1. Multiple Choice Questions. (16×1=16)
The nuclei having spin quantum number greater than show
NMR phenomenon.
1 2
3 0
is a component of mass instrument.
Detector Mass analyzer
A and B Radio frequency transmitter
peak has mass to charge ratio more than the molecular ion
peak.
Isotopic Fragment ion
Metastable ion All of these
Grammage test is carried out on packaging material.
Corrugated box Paper
Aluminium foil All of these
is a validation parameter used for analytical method by UV
method.
Accuracy Precision
A and B Roughness
No. of signals in NMR spectrum for 5-trimethyl benzene molecule
Two Five
Six One
is not a ion source used in mass spectrometer.
Electron impact Magnet
Fast atom bombardment Field desorption
The chemical shift value in the NMR spectrum is denoted by
β α
δ
study verifies that the response is linearly proportional to
the analyte concentration in the concentration range of sample solution.
Selectivity Linearity
Sensitivity None of these
10) The most intense peak in the mass spectrum is called as
Base peak Rearrangement ion peak
Isotope ion peak Molecular ion peak
11) is the sum total of organized arrangement made with the
objective of insuring that medicines are of the desired quality.
Process validation Equipment validation
Quality assurance Quality control
12) is not a type of process validation.
Revalidation Current validation
Prospective validation Concurrent validation
13) The arithmetic mean for the given values such as 15, 25, 35 and 45 is
20 30 25 15
14) Coupling constant for cis protons is
0-5 Hz 11-18 Hz
6-15 Hz 6 Hz
15) Which of the following test are carried out for pharmaceutical packaging
material
Hydrolytic resistance Grammage
Tensile strength All of these
16) ion peak gives information about molecular mass of the analyte.
Molecular Fragment
Isotope Metastable
2. Answer any four of the following questions.
Draw a neat labeled diagram of NMR spectrometer. Why TMS is used as
internal standard
Give principle involved in mass spectroscopy.
Distinguish between quality assurance and quality control.
Write on quality control test carried on glass as packaging material.
Write in short on process validation.
3. Answer any four of the following questions
Write on types of ions produced in mass spectrometry.
Write in short on Quality Assurance.
Write a note on applications of NMR spectroscopy.
Explain with suitable examples standard deviations and median.
Write on bursting strength and carton drop test of packaging material.
4. Answer any two of the following questions
Explain in detail on chemical shift.
Explain with suitable diagram quadrupole mass analyzer. Write on quality
management system.
Write on t-test. Write on quality control test carried on rubber closure.
5. Answer any two of the following questions
Explain with suitable diagram any two ion sources used in mass spectrometry.
Explain with suitable examples spin-spin coupling.
Write on validation of analytical method by UV method.