B.Pharm. (Semester VIII) Examination, 2017
PHARMACEUTICAL ANALYSIS VI
Day and Date Thursday, 7-12-2017 Total Marks 80
Time 3.00 p.m. to 6.00 p.m.
I. Multiple choice questions (16×1=16)
All solvents are used to record NMR except
CDCl3 DMSO-d6
C2H5OH CCl4
The largest peak in mass spectrum is called as
Metastable peak Base peak
Parent ion peak Daughter peak
The weights of five tablets were found to be 160 mg, 137 mg, 149 mg,
153 mg and 161 mg respectively. The mean weight of the tablet is
160 mg 148 mg
152 mg 146 mg
Which of the following test will you perform for assessing quality of paper as
packaging material
Grammage
Water vapour transmission rate
Folding endurance test
All of the above
The bombarding electrons capable of producing ion in a mass spectrometer
have energy about
20 ev 70 ev 100 ev 25 ev
No. of signals in NMR spectrum for toluene molecule
one three two four
Which one of the following hydrocarbons produces an NMR spectrum with
more than one peak
methane ethane
butane cyclobutane
Which of the following is normally detected by mass spectrometry
Positive ion Negative ion
Radical All of the above
The ability of a method to remain unaffected by small but deliberate variations
is called
Repeatability Reproducibility
Robustness Intermediate precision
10) Which of the following test is performed for plastic packaging material for
non parenteral use
Leakage test
Non volatile residue
Clarity of aqueous extract
All of the above
11) Which of the following is a component of quality management system
cGMP Quality assurance
Quality control All of these
12) The lowest amount of analyte in a sample which can be quantitatively
determined with suitable precision and accuracy is called
Detection limit Quantitation limit
Specificity Robustness
13) Vicinal coupling is
Coupling between 1H nuclei attached to the same C atom
Coupling between 1H nuclei attached to adjacent C atoms
Coupling between 1H nuclei in an alkane
Coupling between 1H nuclei in an alkene
14) NMR phenomenon is not shown by nuclei.
13C 16O 1H 15N
SLR-TH 47
Set P
15) Characteristic feature of a Tropylium ion is that it contains a
membered ring.
Five Six Eight Seven
16) Faraday cup acts as in mass spectrometer.
Detector Capacitor
Analyser Collector
II. Answer any four of the following questions
Which standard is used in NMR Justify.
Enlist ionisation methods used in mass spectrometry. Explain electrospray
ionization.
Explain normal distribution.
Give the applications of mass spectrometry.
Explain the folding endurance test for paper as packaging material.
III. Answer any four of the following questions
Elaborate on quality control tests for plastic as a packaging material.
Explain in detail the test for determination of moisture vapour transmission
rate of packaging material.
Write on equipment validation.
Define the terms
Robustness
ii) Specificity
iii) Accuracy
iv) Precision.
Define the terms
Standard deviation
ii) Mean
iii) Median
iv) Mode.
IV. Answer any two of the following questions
Draw diagram of double focusing mass analyzer. Add a note on Mc Lafferty
rearrangement. Enlist types of ions produced in mass spectrometry.
What is chemical shift Explain the factors affecting chemical shift.
Write in detail about Batch Production and Control Record.
V. Answer any two of the following questions
Write a note on fragmentation patterns in mass spectrometry.
Explain in detail coupling constant in NMR. Also add a note on applications
of NMR.
Explain instrumentation involved in NMR spectroscopy with a neat labeled
diagram. Write on bursting strength test carried for packaging material.