Exam Details
| Subject | pharmaceutical analysis – vi | |
| Paper | ||
| Exam / Course | b. pharmacy | |
| Department | ||
| Organization | solapur university | |
| Position | ||
| Exam Date | March, 2018 | |
| City, State | andhra pradesh, solapur |
Question Paper
B.Pharm. (Semester VIII) (New CGPA) Examination, 2018
Pharmaceutical analysis vi
Day and Date Monday, 14-5-2018 Total Marks 70
Time 3.00 p.m. to 6.00 p.m.
1. Multiple Choice Questions (15×1=15)
Nuclei having spin quantum number zero, shows NMR phenomenon.
(greater than) (equals to)
(less than) None of these
The chemical shift delta ppm value for aldehydic proton is
6 8 4 6 9.5 10 11 12
Multiplicity of the peak in NMR spectroscopy is given by rule.
Hydrolytic resistance test is carried out for packaging material.
Plastic Glass
Rubber closure Aluminium foil
Reducing substance test is carried out for packaging material.
Plastic Rubber closure
and Glass
Number of signals for 1,3-dibromopropane is
3 2 4 6
is not a component of mass spectrometry instrument.
Ion source Detector
Sample inlet system Magnet
Molecular ion peak in the mass spectrum gives information about of the analyte sample.
Isotope Mass
Molecular formula Empirical formula
Which of the followings are the components of quality management system
Quality assurance Quality control
Good manufacturing practice All of these
P.T.O.
SetP
Seat
No.
Set P
SLR-TA 53 *SLRTA53*
10) is the most frequently occurring value in a series of a observation.
Mode Mean Median Standard deviation
11) is a ability to elicit tests that are directly or by a well defined mathematical transformations proportional to the concentration of analyte in sample within a given range.
Accuracy Specificity Linearity Range
12) Revalidation is carried out when there is a
Change in equipment Change in procedures
Change in formulae All of these
13) validation is the process by which it is established by laboratory studies that the performance characteristics of the method meet the requirements for the intended analytical applications.
Analytical method Process
Equipment Product
14) Standard deviation is obtained by taking
Square of the variance Square root of the median
Square standard error of mean Square root of the variance
15) What is the median of the data 10, 12, 8
4 5.5 4.5 5
2. Answer any five of the following questions
Write a note on f-test.
Draw a neat labeled diagram of mass spectrometer. Give its principle.
What is chemical shift Why TMS is used as internal standard
Write on process validation.
What is packaging material Describe grammage and carton drop test.
Write on solvents used in NMR spectroscopy. Enlist applications of NMR spectroscopy.
3. Answer any three of the following questions (3×10=30)
Write on various parameters used in validation of analytical method as per ICH.
Explain with suitable diagram MALDI and electrospray ionization as an ion source in mass spectrometry.
Explain with suitable examples spin-spin coupling. Draw the structure of organic sample having molecular formula C4H7O2Br2 with NMR signals at 10.97 δ as singlet, 2.0 δ as quintet and 1.0 δ as triplet.
Write on general rules of fragmentation and types of ions produced in mass spectrometry.
Pharmaceutical analysis vi
Day and Date Monday, 14-5-2018 Total Marks 70
Time 3.00 p.m. to 6.00 p.m.
1. Multiple Choice Questions (15×1=15)
Nuclei having spin quantum number zero, shows NMR phenomenon.
(greater than) (equals to)
(less than) None of these
The chemical shift delta ppm value for aldehydic proton is
6 8 4 6 9.5 10 11 12
Multiplicity of the peak in NMR spectroscopy is given by rule.
Hydrolytic resistance test is carried out for packaging material.
Plastic Glass
Rubber closure Aluminium foil
Reducing substance test is carried out for packaging material.
Plastic Rubber closure
and Glass
Number of signals for 1,3-dibromopropane is
3 2 4 6
is not a component of mass spectrometry instrument.
Ion source Detector
Sample inlet system Magnet
Molecular ion peak in the mass spectrum gives information about of the analyte sample.
Isotope Mass
Molecular formula Empirical formula
Which of the followings are the components of quality management system
Quality assurance Quality control
Good manufacturing practice All of these
P.T.O.
SetP
Seat
No.
Set P
SLR-TA 53 *SLRTA53*
10) is the most frequently occurring value in a series of a observation.
Mode Mean Median Standard deviation
11) is a ability to elicit tests that are directly or by a well defined mathematical transformations proportional to the concentration of analyte in sample within a given range.
Accuracy Specificity Linearity Range
12) Revalidation is carried out when there is a
Change in equipment Change in procedures
Change in formulae All of these
13) validation is the process by which it is established by laboratory studies that the performance characteristics of the method meet the requirements for the intended analytical applications.
Analytical method Process
Equipment Product
14) Standard deviation is obtained by taking
Square of the variance Square root of the median
Square standard error of mean Square root of the variance
15) What is the median of the data 10, 12, 8
4 5.5 4.5 5
2. Answer any five of the following questions
Write a note on f-test.
Draw a neat labeled diagram of mass spectrometer. Give its principle.
What is chemical shift Why TMS is used as internal standard
Write on process validation.
What is packaging material Describe grammage and carton drop test.
Write on solvents used in NMR spectroscopy. Enlist applications of NMR spectroscopy.
3. Answer any three of the following questions (3×10=30)
Write on various parameters used in validation of analytical method as per ICH.
Explain with suitable diagram MALDI and electrospray ionization as an ion source in mass spectrometry.
Explain with suitable examples spin-spin coupling. Draw the structure of organic sample having molecular formula C4H7O2Br2 with NMR signals at 10.97 δ as singlet, 2.0 δ as quintet and 1.0 δ as triplet.
Write on general rules of fragmentation and types of ions produced in mass spectrometry.
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Subjects
- anatomy, physiology and health education – i
- anatomy, physiology and health education – ii
- biochemistry
- biochemistry – i
- biochemistry – ii
- biopharmaceutics
- biotechnology
- clinical pharmacology
- herbal technology
- human anatomy and physiology – i
- human anatomy and physiology – ii
- medicinal chemistry – i
- medicinal chemistry – ii
- medicinal chemistry – iv
- microbiology
- modern dispensing and hospital pharmacy
- novel drug delivery systems
- organic chemistry – i
- organic chemistry – ii
- organic chemistry – iii
- pathophysiology (new cbcs)
- pathophysiology and clinical biochemistry – i
- pathophysiology and clinical biochemistry – ii
- pharmaceutical analysis – i
- pharmaceutical analysis – ii
- pharmaceutical analysis – iv
- pharmaceutical analysis – v
- pharmaceutical analysis – vi
- pharmaceutical busines management
- pharmaceutical engineering
- pharmaceutical enginering
- pharmaceutical inorganic chemistry
- pharmaceutical jurisprudence
- pharmaceutical microbiology
- pharmaceutical organic chemistry – ii
- pharmaceutical organic chemistry –i
- pharmaceutics – i (new cbcs)
- pharmaceutics – i (old-cbcs pattern)
- pharmaceutics – ii
- pharmaceutics – iii
- pharmaceutics – iv
- pharmacognosy – i
- pharmacognosy – ii
- pharmacognosy – iii
- pharmacology – i (new) (cbcs pattern)
- pharmacology – ii
- pharmacology – ii (cgpa pattern)
- pharmacology – iv
- physical pharmaceutics – i
- physical pharmacy – i
- physical pharmacy – ii
- sterile dosage forms