Exam Details
| Subject | medicinal chemistry – iv | |
| Paper | ||
| Exam / Course | b. pharmacy | |
| Department | ||
| Organization | solapur university | |
| Position | ||
| Exam Date | 12, May, 2017 | |
| City, State | andhra pradesh, solapur |
Question Paper
B.Pharm. (Semester VIII) Examination, 2017
MEDICINAL CHEMISTRY IV
Day and Date Friday, 12-5-2017 Total Marks 80
Time 3.00 p.m. to 6.00 p.m.
Instructions All questions are compulsory.
Figures to the right indicate marks.
I. Choose the appropriate option. (16×1=16)
Clofibrate is chemically
Ethyl 2-(4-chlorophenoxy)-2-methyl propionate
Ethyl 2-(3-chlorophenoxy)-2-methyl propionate
Ethyl 2-(2-chlorophenoxy)-2-methyl propionate
None of these
Procainamide is chemically
4-amino-N(2-diethylaminoethyl) benzamide
4-amino-N(4-diethylaminoethyl) benzamide
4-amino-N(3-diethylaminoethyl) benzamide
None of these
The drug which inhibits ACE is
Verapamil Captopril Atenolol Reserpine
Gitoxigenin is present in lanatoside
A B C D
Isosorbide dinitrate is used as
Antianginal and Vasodilator Antiarrhythmic agent
Antihyperlipidemic None of these
The NO formed by organic nitrate increases in cell
CGMP CAMP
Intracellular calcium influx None of these
Gemfibrozil is used as agent.
Antihypertensive Adrenergic blocker
Antihyperlipidemic Antianginal
Dihydropyridine nucleus is present in
Nifedipine and Amlodipine Losartan
Ciprofibrate and clofibrate None of these
is cholinesterase reversible inhibitor.
Atropine Cyclopentolate
Neostigmine Pilocarpine
10) The following IA class antiarrhythmic agent contains quinoline nucleus
Procainamide Losartan
Amylnitrate Quinidine
11) 2-Acetyloxy ethyl (trimethyl) azanium is IUPAC name of
Carbachol Bethanechol
Acetylcholine None of these
12) Metyrosine affects the biosynthesis of
Acetylcholine Catecholamine
Atropine None of these
13) Atorvastatin, Simvastatin, Pravastatin are examples of
Sequestering agent HMG CoA reductase Inhibitors
Fibrates None of these
14) The catecholamine nucleus is present in
Ephedrine Amphetamine
Methamphetamine Nor epinephrine
15) Minoxidil contains nucleus in it.
Piperdino pyrimidine Purine
Xanthine None of these
16) is Neuromuscular blocking agent.
Acetyl choline Succinyl choline chloride
Terbutaline Clofibrate
II. Answer any four of the following
Explain types of prodrugs with examples.
Explain the chemistry and MOA of cardiac glycosides.
Add a note on anticholinergic agents.
Classify antianginal agents and write the MOA of organic nitrates.
Write the nomenclature, synthesis and uses of procainamide.
III. Answer any two of the following
Write the biosynthesis and metabolism of catecholamines.
Define and classify antiarrhythmic drugs and write the synthesis of procainamide.
Write the QSAR parameter and explain in detail steric and electronic parameter
QSAR.
IV. Answer any four of the following
Write IUPAC name, synthesis and uses of Propranolol.
Add a note on calcium antagonists with examples.
Add a note on Neuromuscular Blocking agents.
Explain Irreversible cholinesterase inhibitors with examples.
Write the nomenclature, structure and synthesis and uses of Nifedipine
V. Answer any two of the following
Define and classify Antihyperlipidemic agents and write MOA of atorvastatin
and cholestyramine.
Classify antihypertensive agents and explain MOA of ACE inhibitors.
Explain biosynthesis of Acetylcholine and explain SAR and MOA of
Acetylcholine.
MEDICINAL CHEMISTRY IV
Day and Date Friday, 12-5-2017 Total Marks 80
Time 3.00 p.m. to 6.00 p.m.
Instructions All questions are compulsory.
Figures to the right indicate marks.
I. Choose the appropriate option. (16×1=16)
Clofibrate is chemically
Ethyl 2-(4-chlorophenoxy)-2-methyl propionate
Ethyl 2-(3-chlorophenoxy)-2-methyl propionate
Ethyl 2-(2-chlorophenoxy)-2-methyl propionate
None of these
Procainamide is chemically
4-amino-N(2-diethylaminoethyl) benzamide
4-amino-N(4-diethylaminoethyl) benzamide
4-amino-N(3-diethylaminoethyl) benzamide
None of these
The drug which inhibits ACE is
Verapamil Captopril Atenolol Reserpine
Gitoxigenin is present in lanatoside
A B C D
Isosorbide dinitrate is used as
Antianginal and Vasodilator Antiarrhythmic agent
Antihyperlipidemic None of these
The NO formed by organic nitrate increases in cell
CGMP CAMP
Intracellular calcium influx None of these
Gemfibrozil is used as agent.
Antihypertensive Adrenergic blocker
Antihyperlipidemic Antianginal
Dihydropyridine nucleus is present in
Nifedipine and Amlodipine Losartan
Ciprofibrate and clofibrate None of these
is cholinesterase reversible inhibitor.
Atropine Cyclopentolate
Neostigmine Pilocarpine
10) The following IA class antiarrhythmic agent contains quinoline nucleus
Procainamide Losartan
Amylnitrate Quinidine
11) 2-Acetyloxy ethyl (trimethyl) azanium is IUPAC name of
Carbachol Bethanechol
Acetylcholine None of these
12) Metyrosine affects the biosynthesis of
Acetylcholine Catecholamine
Atropine None of these
13) Atorvastatin, Simvastatin, Pravastatin are examples of
Sequestering agent HMG CoA reductase Inhibitors
Fibrates None of these
14) The catecholamine nucleus is present in
Ephedrine Amphetamine
Methamphetamine Nor epinephrine
15) Minoxidil contains nucleus in it.
Piperdino pyrimidine Purine
Xanthine None of these
16) is Neuromuscular blocking agent.
Acetyl choline Succinyl choline chloride
Terbutaline Clofibrate
II. Answer any four of the following
Explain types of prodrugs with examples.
Explain the chemistry and MOA of cardiac glycosides.
Add a note on anticholinergic agents.
Classify antianginal agents and write the MOA of organic nitrates.
Write the nomenclature, synthesis and uses of procainamide.
III. Answer any two of the following
Write the biosynthesis and metabolism of catecholamines.
Define and classify antiarrhythmic drugs and write the synthesis of procainamide.
Write the QSAR parameter and explain in detail steric and electronic parameter
QSAR.
IV. Answer any four of the following
Write IUPAC name, synthesis and uses of Propranolol.
Add a note on calcium antagonists with examples.
Add a note on Neuromuscular Blocking agents.
Explain Irreversible cholinesterase inhibitors with examples.
Write the nomenclature, structure and synthesis and uses of Nifedipine
V. Answer any two of the following
Define and classify Antihyperlipidemic agents and write MOA of atorvastatin
and cholestyramine.
Classify antihypertensive agents and explain MOA of ACE inhibitors.
Explain biosynthesis of Acetylcholine and explain SAR and MOA of
Acetylcholine.
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Subjects
- anatomy, physiology and health education – i
- anatomy, physiology and health education – ii
- biochemistry
- biochemistry – i
- biochemistry – ii
- biopharmaceutics
- biotechnology
- clinical pharmacology
- herbal technology
- human anatomy and physiology – i
- human anatomy and physiology – ii
- medicinal chemistry – i
- medicinal chemistry – ii
- medicinal chemistry – iv
- microbiology
- modern dispensing and hospital pharmacy
- novel drug delivery systems
- organic chemistry – i
- organic chemistry – ii
- organic chemistry – iii
- pathophysiology (new cbcs)
- pathophysiology and clinical biochemistry – i
- pathophysiology and clinical biochemistry – ii
- pharmaceutical analysis – i
- pharmaceutical analysis – ii
- pharmaceutical analysis – iv
- pharmaceutical analysis – v
- pharmaceutical analysis – vi
- pharmaceutical busines management
- pharmaceutical engineering
- pharmaceutical enginering
- pharmaceutical inorganic chemistry
- pharmaceutical jurisprudence
- pharmaceutical microbiology
- pharmaceutical organic chemistry – ii
- pharmaceutical organic chemistry –i
- pharmaceutics – i (new cbcs)
- pharmaceutics – i (old-cbcs pattern)
- pharmaceutics – ii
- pharmaceutics – iii
- pharmaceutics – iv
- pharmacognosy – i
- pharmacognosy – ii
- pharmacognosy – iii
- pharmacology – i (new) (cbcs pattern)
- pharmacology – ii
- pharmacology – ii (cgpa pattern)
- pharmacology – iv
- physical pharmaceutics – i
- physical pharmacy – i
- physical pharmacy – ii
- sterile dosage forms