Exam Details
| Subject | medicinal chemistry – iv | |
| Paper | ||
| Exam / Course | b. pharmacy | |
| Department | ||
| Organization | solapur university | |
| Position | ||
| Exam Date | October, 2018 | |
| City, State | andhra pradesh, solapur |
Question Paper
B. Pharmacy (Semester VIII) Examination, 2018
(CGPA Pattern)
Medicinal Chemistry IV
Day and Date Thursday, 13-12-2018 Total Marks 70
Time 2.30 p.m. to 5.30 p.m.
1. MCQ 15
Nicotinic action of Ach. is blocked by
Atropine d-tubocurarine
Neostigmine None of above
not an irreversible cholinesterase inhibitor.
isofiurophate ecothiophate iodide
neostigmine parathione
drug using as calcium antagonist.
verampamil quinidine amiodarone enalapril
act as long acting organic nitrate.
isosorbide mononitrate nitroglycerine
amylnitrate all of above
For nitroglycerine route is preferred.
Sublingual IM IV All of above
Insertion of bridge in arylethanolamine gives
aryloxypropanolamine act as b-adrenergic blocker.
oxyethylene oxymethylene
oxybutylene none of above
not a direct acting drug.
adrenaline noeadrenaline
isoprenaline amphetamine
drug affect the storage of noradrenaline.
guanithidine reserpine pargyline a-methyl dopa
P.T.O.
Set P
SLR-TV 51 *SLRTV51*
is selective b2 agonist.
salbutamol phenoxybenzamine
tolazoline none of above
10) Acetyl choline is hydrolysed by an enzyme
e-cholinesterase
pesudocholinesterase
none of above
both and
11) is used as antihyperlipemic agent.
clofibrate amyl nitrate
digitalis tolazoline
12) The drug which inhibits ACE is
captopril amlodepine
amiodarone quinidine
13) Which one of the following is MOA of Lovastatin
Increase 7-a hydroxylase activity
Increase lipoprotein lipase
Inhibit 3-hydroxy-3-methylglutaryl-CO-A reductase activity
All of above
14) Which of the following is selective b2 stimulant drug.
cholestyramine amlodipine
salbutamol none of above
15) drug block the synthesis of catecholamine.
reserpine guanithidine
metyrosine all
2. Answer any 5 25
Note on Computer aided drug design.
Explain MOA and SAR of acetyl choline.
Classify parasympathomimetic agent and explain solanaceae alkaloidal drug.
Set P
*SLRTV51* SLR-TV 51
Write classification b-adrenergic blockers drugs and explain SAR of it.
Classify antihyperlipidemic drug and note on HMG-COA reductase inhibiters.
Write synthesis and uses of
Procainamide
Cyclopentolate.
3. Answer any 3 30
Explain in detail biosynthesis, storage and release and metabolism of NA
from amino acid with structure and enzyme involved it.
Define and classify antihypertensive agent explain MOA and SAR of ACE
inhibitor.
Define QSAR and explain in detail physiological parameters of it.
Define pro-drug, classify it and explain in detail examples with advantages.
(CGPA Pattern)
Medicinal Chemistry IV
Day and Date Thursday, 13-12-2018 Total Marks 70
Time 2.30 p.m. to 5.30 p.m.
1. MCQ 15
Nicotinic action of Ach. is blocked by
Atropine d-tubocurarine
Neostigmine None of above
not an irreversible cholinesterase inhibitor.
isofiurophate ecothiophate iodide
neostigmine parathione
drug using as calcium antagonist.
verampamil quinidine amiodarone enalapril
act as long acting organic nitrate.
isosorbide mononitrate nitroglycerine
amylnitrate all of above
For nitroglycerine route is preferred.
Sublingual IM IV All of above
Insertion of bridge in arylethanolamine gives
aryloxypropanolamine act as b-adrenergic blocker.
oxyethylene oxymethylene
oxybutylene none of above
not a direct acting drug.
adrenaline noeadrenaline
isoprenaline amphetamine
drug affect the storage of noradrenaline.
guanithidine reserpine pargyline a-methyl dopa
P.T.O.
Set P
SLR-TV 51 *SLRTV51*
is selective b2 agonist.
salbutamol phenoxybenzamine
tolazoline none of above
10) Acetyl choline is hydrolysed by an enzyme
e-cholinesterase
pesudocholinesterase
none of above
both and
11) is used as antihyperlipemic agent.
clofibrate amyl nitrate
digitalis tolazoline
12) The drug which inhibits ACE is
captopril amlodepine
amiodarone quinidine
13) Which one of the following is MOA of Lovastatin
Increase 7-a hydroxylase activity
Increase lipoprotein lipase
Inhibit 3-hydroxy-3-methylglutaryl-CO-A reductase activity
All of above
14) Which of the following is selective b2 stimulant drug.
cholestyramine amlodipine
salbutamol none of above
15) drug block the synthesis of catecholamine.
reserpine guanithidine
metyrosine all
2. Answer any 5 25
Note on Computer aided drug design.
Explain MOA and SAR of acetyl choline.
Classify parasympathomimetic agent and explain solanaceae alkaloidal drug.
Set P
*SLRTV51* SLR-TV 51
Write classification b-adrenergic blockers drugs and explain SAR of it.
Classify antihyperlipidemic drug and note on HMG-COA reductase inhibiters.
Write synthesis and uses of
Procainamide
Cyclopentolate.
3. Answer any 3 30
Explain in detail biosynthesis, storage and release and metabolism of NA
from amino acid with structure and enzyme involved it.
Define and classify antihypertensive agent explain MOA and SAR of ACE
inhibitor.
Define QSAR and explain in detail physiological parameters of it.
Define pro-drug, classify it and explain in detail examples with advantages.
Other Question Papers
Subjects
- anatomy, physiology and health education – i
- anatomy, physiology and health education – ii
- biochemistry
- biochemistry – i
- biochemistry – ii
- biopharmaceutics
- biotechnology
- clinical pharmacology
- herbal technology
- human anatomy and physiology – i
- human anatomy and physiology – ii
- medicinal chemistry – i
- medicinal chemistry – ii
- medicinal chemistry – iv
- microbiology
- modern dispensing and hospital pharmacy
- novel drug delivery systems
- organic chemistry – i
- organic chemistry – ii
- organic chemistry – iii
- pathophysiology (new cbcs)
- pathophysiology and clinical biochemistry – i
- pathophysiology and clinical biochemistry – ii
- pharmaceutical analysis – i
- pharmaceutical analysis – ii
- pharmaceutical analysis – iv
- pharmaceutical analysis – v
- pharmaceutical analysis – vi
- pharmaceutical busines management
- pharmaceutical engineering
- pharmaceutical enginering
- pharmaceutical inorganic chemistry
- pharmaceutical jurisprudence
- pharmaceutical microbiology
- pharmaceutical organic chemistry – ii
- pharmaceutical organic chemistry –i
- pharmaceutics – i (new cbcs)
- pharmaceutics – i (old-cbcs pattern)
- pharmaceutics – ii
- pharmaceutics – iii
- pharmaceutics – iv
- pharmacognosy – i
- pharmacognosy – ii
- pharmacognosy – iii
- pharmacology – i (new) (cbcs pattern)
- pharmacology – ii
- pharmacology – ii (cgpa pattern)
- pharmacology – iv
- physical pharmaceutics – i
- physical pharmacy – i
- physical pharmacy – ii
- sterile dosage forms