B.Pharmacy (Semester VIII) Examination, 2017
NOVEL DRUG DELIVERY SYSTEMS
Day and Date Friday, 5-5-2017 Total Marks 80
Time: 3.00 p.m. to 6.00 p.m.
Instructions • All questions are compulsory.
• Figures to right indicate full marks.
I. Choose the appropriate answer from the following choices (16×1=16)
Soluble erodible polymer membranes follow principle of drug
release.
Dissolution Osmosis
Diffusion Diffusion and dissolution
Powder aerosol is an example of phase system.
Three Two
One Four
Small intestine is the potential site for drug absorption because of
Microvili Acid secretion
More viscous contents Less surface area
aerosols systems contain lowest amount of water.
Two phase Three phase
One phase All
Soft, flexible and hydrophilic contact lenses contain
Polymethylmethacrylate Hydroxyethyl methacrylate
Silicone derivatives All of above
belong to the class of non-biodegradable polymers.
Hydroxypropyl methyl cellulose Polyethylene glycol
Polyvinyl pyrrolidone None of these
Enteric coated tablets are examples of release systems.
Immediate Slow and continuous
Sustained Delayed
Total pressure of an aerosol system can be determined by
Rault's Law Dalton's Law
Avagadro's Law None of the above
BCS class-II drugs posses permeability and
solubility.
High, low Low, low
High, high Low, high
10) Bioadhesive drug delivery is an example of
Delayed transit and continuous release
Slow and continuous release
Delayed release
Conventional release
11) Space spray contains of propellant.
Up to 30 80-98
Up to 10 Up to 5
12) Peyer's patches are used as carriers for drug release in
Stomach Buccal
Colon Intestine
13) excipient are permitted to be used in DPIs.
Lactose Calcium stearate
Magnesium stearate All of these
14) Size based drug delivery systems are designed to release the drug
in
Oral cavity Colon
Stomach Small intestine
15) The maintenance dose in an oral CRDDS depends upon
Bioavailability Clearance
Plasma concentration All of these
16) The numerical designation for propellant Difluoroethane is
125 152a
25b 512
II. Answer any four 16
Explain the role of tortuosity and porosity in a matrix system.
Write a note on three phase aerosol systems.
Write a note on intra-uterine devices.
Give the design of a metering valve.
Discuss in brief approaches to design Floating Drug Delivery System.
III. Answer any four 16
Define and classify modified release drug delivery systems.
Describe metal as container material used for pharmaceutical aerosols.
Write a note on Colon-Specific Drug Delivery System.
Discuss different classes of polymers used in the design of oral CRDDS.
Describe the general method of numbering the propellants.
SLR-D 42
IV. Answer any two 16
Describe the problems associated with bioadhesive systems.
Give an exhaustive review of dry powder inhalers.
Describe different techniques to achieve modified release in design of oral CRDDS.
V. Answer any two 16
Describe the in-vitro tests to evaluate drug release of modified release drug
delivery systems.
Explain in detail the design of a metered-dose pharmaceutical aerosol.
Discuss the principle and design of Osmotically controlled devices.