B.Pharm. (Semester VIII) (New CGPA Pattern) Examination, 2018
novel drug delivery systems
Day and Date Friday, 4-5-2018 Max. Marks :70
Time 3.00 p.m. to 6.00 p.m.
1. Multiple Choice Questions/Objective type questions (15×1=15)
Lupron implant is an example of
Erodible implant Implant pump
Both and None of these
For maximum bioavailability, drug should be targeted at
Stomach Small intestine
Large intestine Colon
Wicking agent is responsible for
Repelling water molecules Attracting water molecules
Repelling drug molecules Attracting drug molecules
The specific gravity of hydro dynamically balanced DDS should be in between
1.300 1.401 1.425 1.535 1.004 1.010 1.125 1.365
For describing drug release by diffusion, which model fitting is suitable
Zero order First order
Higuchi model Hixon-crowel model
A tablet which does not release promptly after ingestion is known as
Extended release Sustained release
Delayed release All of these
Hydrophillic matrices are known as
Swellable systems Non-swellable systems
Insoluble plastic systems All of these
Eudragit S-100 is soluble at pH more than
7 6 5 4
Majorly Hydrophilic polymer contains group.
Amino Carboxyl Hydroxyl All of these
P.T.O.
Set P
SLR-TA 50 *SLRTA50*
10) GTT indicates polymer transition from state.
Rubbery to glassy Glassy to rubbery
Liquid to vapour None of these
11) Polymethacrylates belongs to the class of
Vinyl polymers Cellulose esters
Silicones Polyesters
12) Acacia is a type of polymer
Polysaccharides Cellulose esters
Silicones Polyesters
13) For skin DDS is the main hurdle for drug absorption
Stratum corneum Epidermis
Dermis Subcutaneous tissue
14) BCS class three drugs have permeability and solubility.
High, high Low, high High, low Low, low
15) For the testing of dosage form pooled sample is applicable for
Immediate release Extended release
Sustained release Both and
2. Solve any five
Give the advantages and disadvantages of NDDS in detail.
Discuss the applications of polymers in CRDDS.
Give the pre-requisites of drug candidates for NDDS.
Discuss the use of ion-exchange system for taste masking of drug.
Elaborate iontophoresis and sonophoresis for delivery of drug.
Discuss liposomes and resealed erythrocytes as a drug delivery system.
3. Solve any three (10×3=30)
Explain colon targeted DDS.
Discuss diffusion and dissolution controlled drug release approaches for designing NDDS.
Discuss osmotic drug delivery systems.
Compare the release monographs of different dosage forms.