B.Pharm. (Semester VIII) (CGPA) Examination, 2018
novel drug delivery systems
Day and Date Saturday, 8-12-2018 Max. Marks 70
Time 2.30 p.m. to 5.30 p.m.
1. Multiple Choice Questions/Objective type questions (15×1=15)
Pooled samples are utilized for
Immediate release Extended release
Sustained release Both a and b
The Stratum corneum is hard to penetrate because of
High concentration of keratin High concentration of melanin
Presence of hair follicles Presence of Sweat glands
Chitosan is a type of polymer
Polysaccharides Cellulose esters
Silicones Polyesters
Glass transition temperature indicates polymer transition from
state.
Rubbery to glassy Glassy to rubbery
Liquid to vapour None of these
The group responsible for lipophillicity of polymer
Amino Carboxyl
Hydroxyl None of these
The maintenance dose is responsible for
Stedy-state plasma concentration
More than maximum effective concentration
Minimum effective concentration
None of these
For describing the drug release kinetics from the matrix system containing
water soluble drug which model fitting is suitable
Zero order First order
Higuchi model Hixon-crowel model
Seat
No. Set P
Set P
SLR-TV 49 *SLRTV49*
A Tablet which releases promptly after ingestion is known as
Extended release Sustained release
Delayed release Immediate release
Lipophillic matrices are known as
Swellable systems Non-swellable systems
Soluble systems All of these
10) Eudragit L-100 is soluble at pH more than
7 6 5 4
11) Poly(acrylic acid) carbomer belongs to the class of
Vinyl polymers Cellulose esters
Silicones Polyesters
12) Enteric coated tablet is an example of which system
Extended release Delayed release
Sustained release Immediate release
13) Which part of GIT is a host of numerous bacteria
Stomach Small intestine
Large intestine Colon
14) Hydrophillic drugs are highly
Permeable Soluble
Less permeability Both b and c
15) Pulsincap is an example of targeted DDS.
brain skin
colon nose
2. Solve any five
Give the terms used and commercial importance of NDDS.
Discuss the classification of polymers in CRDDS.
Give the physiological factors to be consider for developing NDDS.
Discuss IUD's and sonophoresis for delivery of drug.
Elaborate ocular drug delivery systems.
Discuss any two kinetic model of drug release.
3. Solve any three (10×3=30)
Explain gastroretentive drug delivery systems.
Discuss pre-requisites of drug and biopharmaceutical consideration for the
designing of NDDS.
Discuss different approaches for the delivery of drug to the distal part of GIT.
Give the classification of NDDS.