B. Pharmacy (Semester Examination, 2017
New CGPA Pattern
BIOPHARMACEUTICS
Day and Date Saturday, 6-5-2017 Total Marks 70
Time 10.30 a.m. to 1.30 p.m.
1. Multiple Choice Questions 15
Passive diffusion
Means 90% of drugs get absorbed
Is usually slow
Requires no energy
All of the above
The initial distribution of a drug into tissue is determined chiefly
by
Rate of blood flow to the tissue
Affinity for the tissue
Plasma protein binding of the drug
Stomach emptying time
The area under the plasma level time profile curve represented
the
Amount of drug excreted in urine
Amount of drug absorbed
Amount of drug that is cleaned by the kidney
Biological half-life of the drug
The volume of distribution of a drug is
An expression of total body volume
A measure of total fluid volume
A relationship between the total amount of drug in the body and the concentration
of the drug in the blood
Proportional to bioavailability of the drug
The rate and extent of drug reaching the systemic circulation is called
as
Absorption Disposition
Clearance Bioavailability
drugs are easily excreted by the kidney.
Water soluble Lipid soluble
Volatile None of the above
The time required for drugs to start producing pharmacological response is
known as
Duration of action Onset of action
Onset time Therapeutic index
If the molecular weight of drug is more than 500 Daltons it mainly excreted by

Kidney Bile
Both a and b None of the above
Which of the following is a cause of non-linearity
Drug absorption Drug metabolism
Drug excretion All of the above
10) is considered as pharmacokinetics methods of measurement
of bioavailability.
Acute pharmacological response Therapeutic response
Urinary excretion studies None of the above
11) False nutrients are absorbed by mechanism of drugs
absorption.
Passive diffusion Ions pair transport
Carrier mediated transport Endocytosis
SLR-D 22
12) Orosomucoid means
Binding of drug to 1 α -Acid Glycoprotein
Binding of drug to Lipoproteins
Binding of drug to Globulins
Binding of drug to Blood cells
13) Gastric emptying is not affected by
Volume of the meal Body posture
Type of dosage form Emotional state
14) Danckwert's model of drug dissolution is also known as
Film theory Limited solvation theory
Surface renewal theory Interfacial barrier model
15) In IV bolus administration can be neglected.
Absorption Elimination
Distribution All of the above
2. Answer any five 25
What is non-linear pharmacokinetics Explain in detail its causes with
examples.
Define the term gastric emptying. Explain factors affecting it.
How ionic drugs are absorbed
Define
Bioavailability
Bioequivalence.
Cmax.
Minimum effective concentration.
Therapeutic index.
Give the factors affecting protein-drug binding. Add a note on drug related
factors.
Discuss briefly the influence of pharmaceutical excipients on drug absorption.
3. Answer any three 30
Enlist factors affecting absorption of drug. Describe the physiochemical
properties of drugs affecting on it.
What is non-linear pharmacokinetics Why non-linearity is observed in
absorption, distribution and elimination
Why distribution of a drug is not uniform throughout the body Enlist the
different physiological barriers to distribution of drug. Add a note on placental
barriers is not as effective as BBB.
What are the various non-renal routes of drug excretion Explain in detail
biliary excretion of drugs.