B.Pharm. (Semester (CGPA) Examination, 2018
Biopharmaceutics
Day and Date Saturday, 5-5-2018 Max. Marks 70
Time 10.30. a.m. to 1.30. p.m.
1. Multiple choice questions. (15×1=15)
Which of the following formulation shows better bioavailability
Tablets Capsule
Suspension Emulsion
Blood brain barrier constitutes of
Mesoblast basement membrane
Glial cells and astrocytes
Trophoblast basement membrane
Sertoli-Sertoli cell junction
Which of the following is a Phase I biotransformation process
Oxidation Glucouronidation
Acetylation Methylation
Elimination phase of a drug can be characterized by
KE T1/2
Clearance All of the above
The arrangement of compartments similar to connections of satellite to planet is seen in
Mammilary model Caternary model
Non-compartment model Physiologic model
Parameter(s) considered important for the determination of bioavailability is/are
Cmax Tmax
AUC All of the above
Seat
No.
Set
P
Set P
SLR-TA 33 *SLRTA33*
As per-Fick's First Law of diffusion, which of the following is not directly proportional to diffusion rate
Area of absorbing membrane Kw/o
Concentration gradient None of the above
If pKa of drug is calculate the extent of ionization at neutral pH.
30% 50% 66.66% 100%
The study of variations in drug response as influenced by circadian rhythm is called as
Clinical Pharmacology Chronopharmacology
Pharmacogenetics Oncology
10) A strongly acidic drug can be better excreted in urine.
Acidic Alkaline
Neutral Independent of urine pH
11) The drug remaining in the body after 4 half-lives is
25% 12.5% 6.25% 3.125%
12) Method of residual is also known as
Feathering Peeling
Stripping All of the above
13) Which of the following is a not pharmacodynamic parameter
Peak plasma concentration Minimum effective concentration
Maximum safe concentration Onset time
14) Which of the following is NOT a downhill process
Passive diffusion Facilitated diffusion
Active transport Electrochemical diffusion
15) Limited salvation theory of dissolution is also known as
Diffusion Model Film theory
Double Barrier theory Surface renewal theory
2. Answer any five of the following questions.
Write a brief note on Biopharmaceutical Classification System.
Write a note on methods of measurement of bioavailability.
Set P
*SLRTA33* SLR-TA 33
Explain the concept of volume of distribution.
Describe entero-hepatic cycling of drugs and its effects.
Write a note on pulmonary excretion and mammary excretion with suitable examples.
Describe the non linear pharmacokinetics with Michaelis Menten equation.
3. Answer any three of the following questions. (3×10=30)
Describe physicochemical factors affecting absorption with emphasis on pH-partition hypothesis.
Describe one compartment open model-IV bolus.
Write a note on protein-drug binding. Describe its effects on various pharmacokinetic parameters.
Define Clearance. Describe factors affecting renal clearance.