M.Sc. Genetics (Semester IV) (CBCS) Examination, 2017
MOLECULAR MEDICINE
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Day Date: Friday, 21-04-2017 Max. Marks: 70
Time: 02.30 PM to 05.00 PM
N.B. Section-I compulsory.
Attempt any four from Section-II
All question carry equal marks.
Draw neat and labeled diagrams wherever necessary.
Section I
Q.1 Rewrite the sentence after choosing the correct answer from
the given alternatives.
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1g) Mutation in BTK gene leads to condition known as
Phenylketonuria Haemoglobinopathies
Agammaglobulinemia Marfan syndrome
2 defined as compouned that demonstrates the
desired biological activity on molecular target.
Lead Genome mercury iron
3 X linked recessive disease.
DMD CFTR BTK Marfan
4 Stem cell exhibits properties.
Only potency Potency and self renewable
Potency and non renewable Only self -renewable
Sickle cell anemia is caused due to replacement of with
amino acid Valine.
Serine glutamic acid isolusine arginine
6 Hematopoietic stem cells are
Pluripotent Totipotent Unipotent oligopotent
PAH gene is mutated in
Phenylketoneuria Chagas disease
Alzheimer's Cystic fibrosis
Definitions. 07
Totipotency
Recombination
Microarray
Lead optimization
Magic bullets
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Down's syndrome
Functional cloning
Section II
Answer any four of the following.
Q.2 Define absorption explain in details factor affecting absorption and add a
note on pharamacogenetics.
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Q.3 Explain in detail process of gene transfer by viruses and other methods. 14
Q.4 Explain in brief properties, types and applications of adult stem cells. 14
Q.5 Answer any two from the following. 14
Write a note on induced pluripotent stem cells.
Explain in brief agammaglobelinemia.
Describe in detail route of administration of drugs.
Q.6 Write short notes on (any two) 14
Give an account on Huntingtin gene mutation.
Explain in brief human genome project
Write a note on Parkinson's disease.