M.Sc. (Semester III) (CBCS) Examination Nov/Dec-2018
Genetics
MOLECULAR MEDICINE
Time: 2½ Hours Max. Marks: 70
Instructions: All questions are compulsory.
Figures to the right indicate full marks.
Q.1 Rewrite the sentences by choosing correct answer from given alternatives: 14
Human Genome project was initiated by
NIH and DOE NIH and EBI
DOE and DDBJ NIH and DDBI
The largest gene in human is
Titin Dystrophin
Insulin Phosphofructokinase
The short DNA fragments that are placed on to a microarray are called
Markers Probes
mRNA Test sequence
Embryonic stem cell isolated from
Gastrula Bone marrow
Blastula Placenta
The common gene delivery system for in vivo gene therapy is
Micro injection Lipofecction
Adeno Viral Vectors Electroporation
of the following is most controversial approach in gene therapy.
Germ line therapy Somatic therapy
Ex-vivo therapy Antisense therapy
SCID stands for
Severe combined Immuno diagnosis
Semi combined immune disease
Severe combined Immuno deficiency
Severe Common Immuno deficiency
In alzheimers disease the patients are observed with plaques which are
formed due to protein.


The CFTR gene is located on chromosome number
7 8
9 3
10) The gammaglobelinemia is caused due to mutation in
CFTR AGL
PKA BTK
Page 2 of 2
SLR-VK-318
11) Blood group system is discovered by scientist.
Thomus Cooly Camillo golgi
Ernst Haeckel Karl Landsteiner
12) Parkinsons disease is a neurodegerative disorder that affects specific area of
the brain called
Substantia nigra Medulla
Cerebrum Olfactory bulb
13) The first draft of HGP was published in 2001 in the journal
Science Cell
Nature Plos Biology
14) Hematopoietic stem cells are
Totipotent Unipotent
Oligopotent Pluripotent
Q.2 Answer the following any four:-
Give any two function of MHC.
Define amniocentesis.
Define Micro-array and give its application.
Define totipotency
Retroviruses
08
Answer the following Any
Define stem cell and its property
Vector used in gene therapy
Applications of DNA fingerprinting
06
Q.3 Answer the following Any
Explain fetal stem cell and its application.
Explain blood groups and antigens.
Explain paternity testing.
08
Answer the following any one
Explain agammaglobelinemia.
Explain bone-regeneration using stem cell.
06
Q.4 Answer the following Any
Explain in silico method in drug designing.
Explain the tissue engineering.
Explain pharmacogenetics.
10
Answer the following any one
Explain Duncchene Muscular Dystrophy
Explain types of viruses used in gene therapy
04
Q.5 Answer the following. (Any two) 14
Explain stem cell as regenerative medicine.
Explain difference between adult and embryonic stem cells with its function.
Explain in detail bioavailability of drugs.