M.Sc. (Semester III) (CBCS) Examination Oct/Nov-2017
Genetics
MOLECUALR MEDICINE
Day Date: Tuesday, 21-11-2017 Max. Marks: 70
Time: 02.30 PM to 05.00 PM
Instructions: All question of Section-I are compulsory.
Answer any Four questions from Section-II.
All questions carry equal marks.
Draw neat and labeled diagrams wherever necessary.
Section-I
Q.1 Rewrite the sentence after choosing the correct answer from the
given alternatives.
07
1g) is mutated in cystic fibrosis.
CFTR Actin
Cadherin Fibrin
2 Nerve tangles in alzheimer's disease is caused due to
protein.
Ameloid beta Tau protein
Sigma Delta
3 Stem cell exhibits properties.
Only potency Potency and self renewable
Potency and non renewable Only self-renewable
4 The gene of haemoglobin is located on chromosome

11 12
16 18
MHC Antigen is human is known
ASB ALC
HLA HSB
6 Mutation in BTK gene leads to condition known
Phenylketonuria Haemoglobinopathies
Agammaglobulinemia Marfan syndrome
is defined as compounded that desired biological
activity on molecular target.
Lead Genome
Mercury Iron
Page 2 of 2
SLR-MK-433
Definitions. 07
DNA fingerprinting.
Pharmacogenetics.
Stem cells.
Positional cloning.
Lead optimization.
In-vivo gene therapy.
Microarray.
Section-II
Answer any of the following.
Q.2 Explain in detail steps involved in drug discovery and its design. 14
Q.3 Write a note on different types of gene therapies. 14
Q.4 Explain in detail process of gene transfer by viruses and other methods. 14
Q.5 Answer any TWO from the following. 14
Give an account on phenyketonuria.
Describe the difference between adult and embryonic stem cells.
Explain in detail prenatal diagnosis and its methods.
Q.6 Write short notes on any TWO of the following. 14
Describe disease related to permanent memory loss.
Describe in detail route of administration of drugs.
Write a note on Parkinson's disease.