Exam Details
| Subject | medicinal chemistry – ii | |
| Paper | ||
| Exam / Course | b. pharmacy | |
| Department | ||
| Organization | solapur university | |
| Position | ||
| Exam Date | March, 2018 | |
| City, State | andhra pradesh, solapur |
Question Paper
B.Pharmacy (Semester VII) (CGPA) Examination, 2018
Medicinal Chemistry III
Day and Date Tuesday, 8-5-2018 Max. Marks 70
Time 3.00 p.m. to 6.00 p.m.
1. Multiple Choice Questions 15
Morphine and heroin differ from each other in respect of
Methyl group on nitrogen
Absence of double bond between C4 and C6
Acetyl group at C3 and C6
Absence of D ring
Some adrenocorticoid are referred to as Δ corticoid because of
High amount of unsaturation in the molecule
Additional double bond in ring
Presence of one double bond in each ring
Absence of double bond in ring A
Estrogen, progestin and Testosterone contain carbon in their nucleus.
19, 21, 18 18, 21, 19 19, 18, 21 18, 19, 21
substituent on the nitrogen of morphine shows antagonist activity.
CH2 CH CH2 CH3
CH2 CH-Ph None of above
Which of the following is mainly anxiolytic drugs
Imipramine lithium
Chlorpromazine Diazepam
Fluoxymestrone is modification of
testosterone estrone
progesterone none
Barbiturate is derivative of
Urea ethylalcohol opium None of above
The chemical behavior of morphine alkaloid is
Acidic Basic Neutral Amphoteric
P.T.O.
Seat
N
o.
Set
P
Set P
Which of the following is not present in opium
Cyclasocine Codeine Thebaine Papaverine
10) Proton pump inhibitor like omeprazole contain following ring system
Pyrimidine Benzimidazole
Benzothiazole Indole
11) molecule contain benzothiazepine nucleus.
Verapamil Amlodipine Cimetidine None of above
12) is the first morphine antagonistic drug.
Nalorphine Naloxone Pentazocine L Levorphanol
13) is the selective COX-2 inhibitor.
Rofecoxib Probenacid
Diphenhydramine Hcl Pronethazine
14) is used as antigout drug.
Allopurinol Probenacid
Acetoaminophen Mefenamic acid
15) is selective serotonin reuptakes inhibitor.
Phenelzine Fluoxetine Clonazepam All
2. Answer any 5 25
Classify NSAID drug and explain MOA and SAR of p-aminophenol derivative.
Note on drugs used in gout disease.
Explain in detail TCA drugs.
Classify anticonvulsant drug and explain SAR of long acting barbiturate.
Classify CNS stimulant drug and explain analeptic drugs.
Classify narcotic analgesic drug and explain modification in morphine nucleus.
3. Answer any 3 30
Classify Hypnotic and Sedative drug and explain MOA and SAR of benzodiazepine.
Classify antihistaminic drug and explain MOA and SAR of proton pump inhibitor.
Classify steroid and explain in detail corpus luteum hormone in detail.
Write synthesis of Aspirin Pentobarbitol Heroin Phenytoin
Diphenhydramine.
Medicinal Chemistry III
Day and Date Tuesday, 8-5-2018 Max. Marks 70
Time 3.00 p.m. to 6.00 p.m.
1. Multiple Choice Questions 15
Morphine and heroin differ from each other in respect of
Methyl group on nitrogen
Absence of double bond between C4 and C6
Acetyl group at C3 and C6
Absence of D ring
Some adrenocorticoid are referred to as Δ corticoid because of
High amount of unsaturation in the molecule
Additional double bond in ring
Presence of one double bond in each ring
Absence of double bond in ring A
Estrogen, progestin and Testosterone contain carbon in their nucleus.
19, 21, 18 18, 21, 19 19, 18, 21 18, 19, 21
substituent on the nitrogen of morphine shows antagonist activity.
CH2 CH CH2 CH3
CH2 CH-Ph None of above
Which of the following is mainly anxiolytic drugs
Imipramine lithium
Chlorpromazine Diazepam
Fluoxymestrone is modification of
testosterone estrone
progesterone none
Barbiturate is derivative of
Urea ethylalcohol opium None of above
The chemical behavior of morphine alkaloid is
Acidic Basic Neutral Amphoteric
P.T.O.
Seat
N
o.
Set
P
Set P
Which of the following is not present in opium
Cyclasocine Codeine Thebaine Papaverine
10) Proton pump inhibitor like omeprazole contain following ring system
Pyrimidine Benzimidazole
Benzothiazole Indole
11) molecule contain benzothiazepine nucleus.
Verapamil Amlodipine Cimetidine None of above
12) is the first morphine antagonistic drug.
Nalorphine Naloxone Pentazocine L Levorphanol
13) is the selective COX-2 inhibitor.
Rofecoxib Probenacid
Diphenhydramine Hcl Pronethazine
14) is used as antigout drug.
Allopurinol Probenacid
Acetoaminophen Mefenamic acid
15) is selective serotonin reuptakes inhibitor.
Phenelzine Fluoxetine Clonazepam All
2. Answer any 5 25
Classify NSAID drug and explain MOA and SAR of p-aminophenol derivative.
Note on drugs used in gout disease.
Explain in detail TCA drugs.
Classify anticonvulsant drug and explain SAR of long acting barbiturate.
Classify CNS stimulant drug and explain analeptic drugs.
Classify narcotic analgesic drug and explain modification in morphine nucleus.
3. Answer any 3 30
Classify Hypnotic and Sedative drug and explain MOA and SAR of benzodiazepine.
Classify antihistaminic drug and explain MOA and SAR of proton pump inhibitor.
Classify steroid and explain in detail corpus luteum hormone in detail.
Write synthesis of Aspirin Pentobarbitol Heroin Phenytoin
Diphenhydramine.
Other Question Papers
Subjects
- anatomy, physiology and health education – i
- anatomy, physiology and health education – ii
- biochemistry
- biochemistry – i
- biochemistry – ii
- biopharmaceutics
- biotechnology
- clinical pharmacology
- herbal technology
- human anatomy and physiology – i
- human anatomy and physiology – ii
- medicinal chemistry – i
- medicinal chemistry – ii
- medicinal chemistry – iv
- microbiology
- modern dispensing and hospital pharmacy
- novel drug delivery systems
- organic chemistry – i
- organic chemistry – ii
- organic chemistry – iii
- pathophysiology (new cbcs)
- pathophysiology and clinical biochemistry – i
- pathophysiology and clinical biochemistry – ii
- pharmaceutical analysis – i
- pharmaceutical analysis – ii
- pharmaceutical analysis – iv
- pharmaceutical analysis – v
- pharmaceutical analysis – vi
- pharmaceutical busines management
- pharmaceutical engineering
- pharmaceutical enginering
- pharmaceutical inorganic chemistry
- pharmaceutical jurisprudence
- pharmaceutical microbiology
- pharmaceutical organic chemistry – ii
- pharmaceutical organic chemistry –i
- pharmaceutics – i (new cbcs)
- pharmaceutics – i (old-cbcs pattern)
- pharmaceutics – ii
- pharmaceutics – iii
- pharmaceutics – iv
- pharmacognosy – i
- pharmacognosy – ii
- pharmacognosy – iii
- pharmacology – i (new) (cbcs pattern)
- pharmacology – ii
- pharmacology – ii (cgpa pattern)
- pharmacology – iv
- physical pharmaceutics – i
- physical pharmacy – i
- physical pharmacy – ii
- sterile dosage forms