THE TAMIL NADU DR. M.G.R. MEDICAL UNIVERSITY
[LN 342] OCTOBER 2018 Sub. Code: 2903
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH I PHARMACEUTICS
PAPER III BIOPHARMACEUTICS AND PHARMACOKINETICS
Q.P. Code 262903
Time Three hours Maximum 100 Marks
I. Elaborate on: x 20 40)
1. Classify and enumerate the factors influencing Bioavailability of drug from its
dosage form.
2. Explain Phase I reaction with examples.
II. Write notes on: (10 x 6 60)
1. Discuss differences between passive and facilitated diffusion.
2. Define protein binding. Explain plasma protein binding and drug distribution.
3. Classify factors affecting biotransformation of drug. Explain chemical factor.
4. Define excretion. Discuss glomerular filtration with neat labeled diagram in
urinary excretion of drugs.
5. Explain zero order kinetics.
6. Explain Michaelis Menten equation.
7. What are the objectives and approaches in developing in vitro-in vivo correlation?
8. Discuss concept of loading and maintenance dose.
9. Give suitable examples of drug- drug interaction.
10. The apparent volume of distribution of a drug is 37 L. If at a given time the
concentration of drug in plasma is 3.2 mcg/ml. Calculate the amount of drug in
body at the time.