OCTOBER 2017 Sub. Code: 2903
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH I PHARMACEUTICS
PAPER III BIOPHARMACEUTICS AND PHARMACOKINETICS
Q.P. Code 262903
Time Three hours Maximum 100 Marks
I. Elaborate on: x 20 40)
1. Explain the phase II bio-transformation reactions with suitable examples.
2. How to determine the pharmacokinetic parameters for a extra vascular by
administered drug which obeys open one compartment model?
II. Write notes on: (10 x 6 60)
1. Write the methods for determining drug absorption.
2. Write the strategies involved in the transport of the drug across blood brain
barrier.
3. Write the factors affecting bio-transformation.
4. Write the principle involved in enterohepatic cycle of drug with an example.
5. Define and derive the first order rate equation and half like equation.
6. Add a note on In vitro In vivo correlation.
7. Write concept involved in total clearance.
8. Write the importance of therapeutic drug monitoring.
9. How to determine dose for renal disease patients?
10. Write the factors affecting pharmacokinetic variability.