MAY 2017 Sub. Code: 2903
M.PHARM. DEGREE EXAMINATION
FIRST YEAR
BRANCH I PHARMACEUTICS
PAPER III BIOPHARMACEUTICS AND PHARMACOKINETICS
Q.P. Code 262903
Time Three hours Maximum 100 Marks
I. Elaborate on: x 20 40)
1. How to determine urinary excretion rate constant by excretion rate method and
sigma minus method for a dry administered by IV bolus and which follows one
compartment open model?
2. Write the protocol for conducting bioequivalence studies. What are the techniques
adopted for bioavailability enhancement of poorly water soluble drugs?
II. Write notes on: (10 x 6 60)
1. Write the pharmaceutical dosage form factors affecting drug absorption.
2. Explain the role of placental and blood brain barrier in drug distribution.
3. Write about glucuronic acid conjugation with example.
4. Explain the kinetics of drug-protein binding.
5. Write any two methods meant for the determination of Km and Vmax.
6. How to determine absorption rate constant by curve fitting method?
7. Differentiate active and passive tubular re-absorption.
8. Pharmacodynamic methods to measure bioavailability.
9. Discuss the effect of multiple drug dosing after oral administration.
10.Write about the dosage adjustment techniques followed in liver disease patients.