THE TAMIL NADU DR. M.G.R. MEDICAL UNIVERSITY
[LN 340] OCTOBER 2018 Sub. Code: 2901
M.PHARM. DEGREE EXAMINATION
(Common to all Branches)
FIRST YEAR
PAPER I MODERN PHARMACEUTICAL ANALYTICAL TECHNIQUES
Q.P. Code 262901
Time Three hours Maximum 100 Marks
I. Elaborate on: x 20 40)
1. Explain the simultaneous equation method and absorbance correction method
for the analysis of multi component dosage forms by UV spectrophotometry.
Write the principle of spectrofluorimetry with a neat labeled diagram and write
the relationship between concentration and fluorescence intensity.
2. Write a note on FT-IR and ATR.
Write a note on 13C-NMR.
II. Write notes on: (10 x 6 60)
1. Explain the various types of ions produced in mass spectrometry.
2. Write a note on circular dichroism.
3. What are the interfaces used in LC-MS? Explain about moving belt interface.
4. Write a note on differential scanning calorimetry.
5. Write short notes on gel electrophoresis.
6. Write a note on precision and accuracy.
7. Briefly explain about super critical fluid chromatography.
8. Write a note on Mc Lafferty rearrangement.
9. Explain the sampling techniques used in IR spectrophotometry.
10. How will calculate the absorbance maximum by using Woodward-Fiesher rule?