M.Sc. DEGREE EXAMINATION, APRIL 2016
Second Semester
Bioinformatics
Elective II — IMMUNOINFORMATICS
(2013 onwards)
Time 3 Hours Maximum 75 Marks
Section A (10 2 20)
Answer all questions.
All questions carry equal marks.
Define
1. Phagocytosis.
2. Cytokines.
3. Adjuvants.
4. Hapten.
5. HLA-DM.
6. Therapeutic vaccines
7. MHC loci.
8. Macrophages.
9. IMGT.
10. Homology Modeling.
Sub. Code
502504
RW-10870
2
WS6
Section B 5 25)
Answer all questions by choosing either or
11. Compare between classic pathway and alternative
pathway of complement activation.
Or
Describe the role of complement in the humoral
immune response.
12. Comment on Antigen recognition diversity.
Or
Explain the process of recognition of antigen by
B cell.
13. Explain the classification of vaccine with suitable
example.
Or
Comment on peptide repertorie of HLA molecules.
14. Write a detail note on computer aided approach in
vaccine design.
Or
Describe in detail about the causes of MHC
polymorphism.
15. Give an account on Databases of MHC ligands.
Or
Write a short note on conserved region.
RW-10870
3
WS6
Section C 10 30)
Answer any three questions.
16. Explain in brief about Hybridoma technology and their
application.
17. Explain MHC molecules and its impact of grafting with
suitable example.
18. Explain in detail about Nomenclature and variability of
HLA.
19. Write in detail note on mathematical model of immune
system.
20. Discuss in detail about prediction of cytotoxic and helper
T cell epitopes using bioinformatics tools.