FACULTY OF PHARMACY
B. Pharmacy 3/4 I Semester (Supplementary) Examination, April 2016
Subject Dosage Formulation and Design (Pharmaceutics-III)
Time 3 hours Max. Marks 70
Note: Answer all questions. All questions carry equal marks.
1 Discuss the effect of the following on the formulation development
Particle size ii) Polymorphism iii) Partition coefficient 9
What is the role of flow properties in preformulation studies? 5
OR
Define stability? Write a short note on accelerated stability testing. 6
Write the reasons and preventive measures for degradation reactions in
formulation Oxidation ii) Hydrolysis 8
2 Write the advantages and disadvantages of sustained action pharmaceuticals. 5
Write a brief note on following sustained release formulations 9
Encapsulated slow release granules
ii) Drug-complex formulation
OR
Define microencapsulation? What are the reasons for microencapsulation? 5
Enumerate the methods for microencapsulation? Describe Coacervationphase
separation technique? 9
3 What are the different types of approaches for Transdermal drug delivery
systems? 7
What are the different types of ocular drug delivery systems available?
Describe the design of Occuserts? 7
OR
Explain in vitro evaluation of Transdermal patches. 6
Write the characterization of liposomes. 8
4 Discuss various methods for assessment of bioavailability. 7
Describe the Latin square experimental design for conducting bioequivalence
study. 7
OR
Define validation? Give the importance of validation of pharmaceuticals. 5
Write about different types of process validation. 9
5 Write about quality control and quality assurance during compounding,
packing and labeling. 8
Write a note on stability protocol of drug products. 6
OR
What is statistical quality control? What are the different types of control
charts available? Write about QC charts for variables and attributes. 10
Write a brief note on Manufacturing Formula Record ii) Batch Production
Record. 4