FACULTY OF PHARMACY
M. Pharmacy (Pharmaceutics) I-Semester (Suppl.) Examination, August 2018
Subject: Modern Pharmaceutics
Time: 3 Hours Max. Marks: 75
Note: Answer any five questions. All questions carry equal marks.
1 Explain the methods for testing of drug excipient compatability studies. 6
Describe the preparation of SMEDDS and their evaluation tests. 6
Define factorial design. Describe the applications and limitations. 3
2 Discuss the ICH guidelines for calibration and validation of equipment with an
example. 8
Describe the validation of tableting process. 7
3 Discuss the sales forecasting and budget planning in pharmaceutical industries. 8
Describe the layout of buildings, services, equipment and their maintenance in
industries. 7
4 What is compaction profile? Explain the phases of compaction profile with a
suitable examples. 5
Define the term intrinsic solubility. How to determine it's significance? 5
Explain the properties of granules effecting the compression behavior of tablets.5
5 Discuss the pharmacokinetic parameters for determination of bioavailability. 5
(b)Describe the comparison of dissolution profiles of dosage forms using similarity
and difference factors. 5
Explain the variance and standard deviation with it's significance. 5
6 Describe the methods of evaluation of physical stability of emulsions. 5
Describe the sterilization procedures for evaluation of parenterals. 5
Describe the chi-square distribution. 5
7 Write the methods for determination of the order of a reaction. 8
Explain the photo degradation and it's testing procedure. 7
8 Discuss the methods for improvement of aqueous solubilty of drugs. 8
Write Heckle equation and draw Heckle plots for porosity and explain them. 7