FACULTY OF PHARMACY
M. Pharmacy (Pharmaceutical Chemistry) I Semester (Main Backlog)
Examination, February 2019
Subject Chemistry of Natural Products
Time 3 hours Max. Marks 75
Note Answer any FIVE questions. All questions carry equal marks.
1 What are alkaloids? Classify alkaloids by giving one example for each class.
Write the general methods to determine the structure of alkaloids. 3+12
2 How natural products acted as leads for the following classes of drugs? Explain.
Macrolide and β-lactam antibiotics
Cardiovascular drugs 8+7
3 Give classification, isoprene and special isoprene rules of interpenoids.
Discuss in brief the structural elucidation of citral and retinol. 3+12
4 Write a note on
Chemistry and physiological significance of vitamins
Gene therapy 9+6
5 How do you characterize the structure of following natural compounds using IR,
1H NMR and 13C NMR spectral data? (Write approximate spectral values)
Morphine
Penicillin G
Vitamin-D
Quercetin
Digoxin 5 x 3 15
6 Write a note on
Chemistry of contraceptive agents
Stereochemistry and nomenclature of steroids
Recombinant DNA technology and drug discovery 3 x 5 15
7 Discuss in detail the structural elucidation of morphine. 15
8 Write down the active constituents present in the following crude drugs with
structures
Swertia chirata ii) Phyllanthus niruri
iii) Curcuma longa iv) Gymnema sylvestre 4 x 2 8
Write the structural elucidation of Quercetin. 7