FACULTY OF PHARMACY
M. Pharmacy (Pharmaceutics) II-Semester (Main) Examination, August 2018
Subject: Advance Biopharmace. Pharmacokinetics
Time: 3 Hours Max. Marks 75
Note: Answer any five questions. All questions carry equal marks.
1 Derive expressions for cmax and tmax for one compartment open model, extra
vascular administration.
Explain with examples cytochrome p450 based drug interactions.
2 What are the different methods for assessment of bioavailability?
What are the special concerns in bioavailability and bioequivalence
studies.
3 Write the significance of different volumes of distribution in two compatment
model.
Write a note on volume of distribution and clearance.
4 Explain various methods to study drug permeability.
Write about IVIVC.
5 Derive Michaelis-Menten equation. How do you estimate Km and Vm.
How do you compare dissolution profiles?
6 Explain the applications of pharmacokinestic principles in controlled release
dosage forms.
Write a note on micro climate intracellular pH and tight junction complex.
7 Enumerate physicochemical factors of the drug affecting dissolution.
Explain the kinetics of IV infusion for one compartment model.
8 Explain various cross over designs in bioequivalence studies.
Write in detail about compartment models.