FACULTY OF PHARMACY
M. Pharmacy (Pharmaceutics) II-Semester (Suppl.) Examination, February 2019
Subject: Advance Biopharmaceutics Pharmacokinetics
Time: 3 Hours Max. Marks: 75
Note: Answer any five questions. All questions carry equal marks.
1. Write in detail about mechanism of drug absorption with suitable diagrams.(10)
State and Explain the Noyes-Whitney equation.
2. Write notes on
pH-Partition hypothesis and its limitations
Explain the pharmacokinetic and pharmacodynamic drug-drug interaction.
3. Discuss about the theories proposed for the dissolution process and the factors
affecting dissolution.
What is in-vitro-in-vivo correlations (IVIVC) and explain in brief.
4. How do you calculate absorption rate constant from plasma-concentration data
following an oral dose using Wagner Nelson method.
Explain the various methods for assessment of bioavailability.
5. Define Non-Linear pharmacokinetics. How do you estimate the pharmacokinetic
parameters (Kmax and Vmax) by using Michaelis-Menten equation.
Explain the biopharmaceutical classification systems with examples and
what are its application
6. Describe the experimental protocol and analysis of data for bioequivalence studies
for conventional dosage form.
Write the application of pharmacokinetics in targeted drug delivery system.
7. Explain the various methods for determining absorption of drugs in-vitro,in-situ
and in- vivo and their correlation with examples.
Pharmacokinetics of 500 mg paracetamol after oral administration is best
described by the equation C=1.18(e-0. 24t
e-1.6t ).Calculate the Cmax, tmax
and t1/2 of the drug.
8. A dose of ciprofloxacin 250 mg I.V.bolus was administered to a patient and the plasma
concentration vs time data is obtained. Assume the drug follows two compartment
open model. Calculate all possible pharmacokinetic parameters.
Time(hrs) 0.25 0.5 0.75 1.5 2 2.5 3 5 6 7
Plasma conc. 5.38 4.33 3.5 2.99 2.12 1.70 1.43 1.05 0.80 0.70