FINAL EXAM NATIONAL BOARD OF EXAMINATIONS
JUNE 2018

POSSESSION/USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE EXAMINATION HALL.
MICROBIOLOGY
PAPER-IV
MIC/J/18/18/IV
Time: 3 hours
Max. Marks:100
IMPORTANT INSTRUCTIONS
Attempt all questions in order.
Each question carries 10 marks.
Read the question carefully and answer to the point neatly and legibly.
Do not leave any blank pages between two answers.
Indicate the question number correctly for the answer in the margin space
Answer all the parts of a single question together.
Start the answer to a question on a fresh page or leave adequate space between two answers.
Draw table/diagrams/flowcharts wherever appropriate.
Write short notes on:
1. Principle of MALDI-TOF and its application in Diagnostic
Microbiology Laboratory.
5+5
2. Discuss the Antibiotic Stewardship Program and its components
(ASP). Describe the role of Microbiologist in ASP.
5+5
3. Non-culture methods for diagnosis of sepsis. 10
4. Define Point-of Care tests. Give an example and describe in
detail the principle of the test.

5. Define vaccine. What are the characteristics of conjugate
vaccines? Give two examples.

6. Classify the phenotypic and genotypic methods used for
determining relatedness of bacteria. Mention the advantages
and disadvantages of any three methods.
4+6
7. Define quality assurance and describe in detail quality
assurance programme for a diagnostic microbiology laboratory.
2+8
8. What is Real-time Polymerase chain reaction? Give its principle.
What are the advantages over the conventional PCR?

9. Enumerate the causes of nosocomial diarrhoea. Write briefly
about hospital infection control programme.
3+7
10. Principle and applications of microarray in Microbiology.
What are edible vaccines and their current status?
5+5