FINAL EXAM NATIONAL BOARD OF EXAMINATIONS
JUNE 2018

POSSESSION/USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE EXAMINATION HALL.
ENDOCRINOLOGY
PAPER-I
ENDO/J/18/07/I
Time: 3 hours
Max. Marks:100
Important Instructions:
Attempt all questions in order.
Each question carries 10 marks.
Read the question carefully and answer to the point neatly and legibly.
Do not leave any blank pages between two answers.
Indicate the question number correctly for the answer in the margin space
Answer all the parts of a single question together.
Start the answer to a question on a fresh page or leave adequate space between two answers.
Draw table/diagrams/flowcharts wherever appropriate.
Write short notes on:
1. Downstream intracellular pathways for prolactin actions.
10
2. Steps of DNA-electrophoretic mobility assay of mutated vitamin
D receptor protein in a patient with rickets and alopecia.
10
3. Molecular players in the development of pituitary gland and
disease related to these molecules.
10
4. What are the phases of normal growth velocity from
intrauterine to adult?
What are the reasons for differences in the average height of
normal females and males?
7+3
5. What are Tolvaptans?
What are their therapeutic indications?
What are their side effects?

6. What is the place of Pegvisomant therapy in growth
hormone excess?
Their mechanisms of action.
7+3
7. Role of autoimmune regulator genes in the development of
Type 1 autoimmune polyglandular syndrome.
10
8. Peripheral immune tolerance
Role of loss of peripheral immune tolerance in the
pathogenesis of autoimmune thyroiditis.
5+5
9. Molecular mimicry, neoantigen and development of Type 1
diabetes.
10
10. Block randomization
Advantages of block randomization in controlled trial.
6+4