B.Pharmacy (Semester VIII) Examination, 2017
PHARMACOLOGY IV
Day and Date Wednesday, 17-5-2017 Total Marks 80
Time 3.00 p.m. to 6.00 p.m.
1. Multiple Choice Questions. (16×1=16)
Select one answer out of four.
"Ototoxicity" is the common adverse effect of following drug
Tetracycline Streptomycin
Erythromycin Chloamphenicol
Anthelminic drug "Praziquantal" is used as the drug of choice to treat
Ochocerchiasis Ascariasis
Schistosomiasis Filariasis
The drug act by inhibition of the enzyme "dihydropteroate synthase".
Sulfamethoxazole Mafenide
Cotrimazole Trimethoprim
Phenoxy methyl penicillin is
Antipseudomonal penicillin Acid resistant penicillin
Penicillinase resistant penicillin Broad spectrum penicillin
Cephalosporin used to treat infection due to gm +ve microorganism
Cefaclor Cefibuten
Cefepime Cefazolin
is a systemic retinoid.
Adapelene Isotretinoin
Azelaic acid Tretinoin
Benign Tertian malaria is caused by
Plasmodium falciparum Plasmodium ovale
Plasmodium malariae Plasmodium vivax
Antimalarial drug used to treat severe form of chloroquine resistant Plasmodium
Falciparum infection.
Mefloquine Atovaquone
Artemissinins Proguanil
Leprosy exhibiting "Skin lesions with nodules, plaques with thick symmetrical
patches".
Borderline lepromatous leprosy Borderline leprosy
Borderline tuberculoid leprosy None of these
10) Antitubercular agent used to treat Isoniazid resistant patients
Pyrazinamide Rifabutin
Ethionamide Ethambutal
11) Anthelmintic action of "Ivermectin" is by
Enhancing Ca2+ permeability via generating reactive oxygen species
Binding to the glutamate sensitive Cl- channel with consequent increase
in Cl- conductance
Binding to β-tubulin inhibits polymerisation of microtubule
Opening nonselective cation channel and activating persistently nicotine
acetylcholine receptor
12) Antineoplastic action of "Paclitaxel" is at the specific phase of the cell cycle
S Phase G1-S Phase
M Phase G2-M Phase
13) Antiviral agent used to treat hepatitis C viral infection
Foscarnet Interferon-α-2B
Lamiuvidine Indinavir
14) Gentamicin action is by
Binding to 30S ribosomal subunit, prevent addition of growing peptide
chain
Inhibiting terminal stage of bacterial cell wall synthesis, "Transpeptidation"
Binding to 30 S ribosomal subunit, incorporate incorrect amino acids
into growing peptide chain
Binding to 50 S ribosomal subunit, interfere with aminoacyl translocation
prevent addition of amino acid to the nascent polypeptide chain
15) Tetracycline used in the treatment of meningococcal infection
Minocycline Oxytetracycline
Chlortetracycline Doxycycline
16) Anti-glaucoma drug "Latanoprost" acts by
Inhibition of carbonic anhydrase thereby reduces formation of bicarbonate ions
Decreasing production of aqueous humor thereby reducing intraocular pressure
Facilitating aqueous humor outflow through the accessory uveoscleral tract
Constriction of Iris sphincter and contraction of ciliary muscle thereby
facilitating outflow of aqueous humor through canal of schlemm
2. Solve any four questions.
Write mechanism, of action, adverse effects and therapeutic uses of macrolide
antibiotics.
Write on Psoriasis and describe photochemotherapy used to treat Psoriasis.
Classify penicillin with examples and explain following drug interaction.
Penicillin Probenecid
Write mechanism of action and adverse effects of "Ciprofloxacin" and explain.
Why Cilastatin is added in combination therapy with Imipenem for the
treatment of Urinary Tract Infection
Classify antiviral drugs with examples.
3. Solve any four questions.
Write on Insulin bioassay.
Write mechanism of action of "Isoniazid" and explain Why pyridoxine is added
in combination therapy of tuberculosis consisting of Isoniazid.
Classify antineoplastic drugs with examples.
Write notes on Zidouvidine ii) Cyclophosphamide
Write mechanism of action and adverse effects of "aminoglycoside antibiotics".
4. Solve any two questions.
Describe various general principles of chemotherapy and add a note on
Antimicrobial resistance.
Classify antifungal agents with examples and write mechanism of action, adverse
effects and therapeutic uses of "Amphotericin-B".
Describe heparin bioassay and add a note on principles of bioassay.
5. Solve any two questions.
Classify tetracyclines with examples. Write mechanism of action, adverse
effects and therapeutic uses of Tetracyclines.
What is Acne Write on drugs used to treat Acne and describe in detail any
two topical retinoids.
Write mechanism of action, adverse effects and therapeutic uses of Co-trimazole
and explain why sulphonamide is avoided in pregnant woman.